Jose A Boga, Maria de Oña, Santiago Melon, Marta E Alvarez-Arguelles, Ana Morilla, Ana Coto-Montes
{"title":"MAVS:对抗病毒感染的新武器。","authors":"Jose A Boga, Maria de Oña, Santiago Melon, Marta E Alvarez-Arguelles, Ana Morilla, Ana Coto-Montes","doi":"10.2174/1872214811307020004","DOIUrl":null,"url":null,"abstract":"<p><p>In addition to their participation in metabolic processes and control of programmed cell death, the role of mitochondria as a fundamental hub for innate anti-viral immunity is now emerging. The participation of the mitochondrial antiviral signaling protein (MAVS) as a central regulator of a complex signaling cascade, which results in the induction of antiviral and inflammatory responses has been described. A patent based on this role of MAVS is highlighted in this review.</p>","PeriodicalId":89474,"journal":{"name":"Recent patents on endocrine, metabolic & immune drug discovery","volume":"7 2","pages":"115-9"},"PeriodicalIF":0.0000,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"MAVS: a new weapon in the fight against viral infections.\",\"authors\":\"Jose A Boga, Maria de Oña, Santiago Melon, Marta E Alvarez-Arguelles, Ana Morilla, Ana Coto-Montes\",\"doi\":\"10.2174/1872214811307020004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In addition to their participation in metabolic processes and control of programmed cell death, the role of mitochondria as a fundamental hub for innate anti-viral immunity is now emerging. The participation of the mitochondrial antiviral signaling protein (MAVS) as a central regulator of a complex signaling cascade, which results in the induction of antiviral and inflammatory responses has been described. A patent based on this role of MAVS is highlighted in this review.</p>\",\"PeriodicalId\":89474,\"journal\":{\"name\":\"Recent patents on endocrine, metabolic & immune drug discovery\",\"volume\":\"7 2\",\"pages\":\"115-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Recent patents on endocrine, metabolic & immune drug discovery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1872214811307020004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent patents on endocrine, metabolic & immune drug discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1872214811307020004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
MAVS: a new weapon in the fight against viral infections.
In addition to their participation in metabolic processes and control of programmed cell death, the role of mitochondria as a fundamental hub for innate anti-viral immunity is now emerging. The participation of the mitochondrial antiviral signaling protein (MAVS) as a central regulator of a complex signaling cascade, which results in the induction of antiviral and inflammatory responses has been described. A patent based on this role of MAVS is highlighted in this review.
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