细胞色素P450 3A mRNA在山羊和大鼠胃肠道的表达。

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Japanese Journal of Veterinary Research Pub Date : 2012-11-01

Dominic Mureithi, Wageh Sobhy Darwish, Yoshinori Ikenaka, Laetitia Kanja, Mayumi Ishizuka

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引用次数: 0

摘要

细胞色素P450 (CYP) 3A家族参与了近50%常用药物的消除过程。采用实时荧光定量PCR技术，比较山羊和大鼠胃肠道中CYP3A mRNA的表达情况。在山羊中，cyp3a样mrna在肝脏中的表达相对高于胃肠道。从十二指肠到回肠，cyp3a样mRNA的表达逐渐降低。在大鼠中，CYP3A62 mRNA在十二指肠中表达最高，其次是肝脏。这项研究为CYP3A酶对异种代谢的贡献提供了见解，特别是在山羊等小型反刍动物中。

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Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts.

The cytochrome P450 (CYP) 3A family is involved in the elimination processes of almost 50% of commonly used drugs. CYP3A mRNA expressions in goat and rat gastrointestinal tracts in comparison to the liver were investigated using real-time PCR. In goats, the expression of CYP3A-like mRNAs was comparatively higher in the liver than in the gastrointestinal tract. The intestinal expression of CYP3A-like mRNA showed a gradual decrease from the duodenum to the ileum. In rats, the highest CYP3A62 mRNA expression was found in the duodenum followed by the liver. This study provides insights into the contribution of CYP3A enzymes to xenobiotic metabolism, especially in small ruminants such as goats.

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来源期刊

Japanese Journal of Veterinary Research 农林科学-兽医学

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： The Japanese Journal of Veterinary Research (JJVR) quarterly publishes peer-reviewed articles on all aspects of veterinary science. JJVR was originally published as a “University Journal” of veterinary science at Hokkaido University from more than 60 years ago. Currently, JJVR, is Japan’s leading scientific veterinary journal, and provides valuable information for the development of veterinary science by welcoming contributions from researchers worldwide. JJVR offers online submission for Regular Papers, Short Communications, and Review Articles that are unpublished and not being considered for publication elsewhere. Research areas include: Anatomy, Physiology, Biochemistry, Pharmacology, Microbiology, Infectious diseases, Parasitology, Laboratory Animal Science and Medicine, Internal Medicine, Surgery, Pathology, Theriogenology, Molecular Medicine, Public Health, Radiation Biology, Toxicology, Wildlife Biology and Medicine, Veterinary Hygiene, The other fields related to veterinary science.