研究内皮活化和氧化应激与多民族人群血糖控制的关系。

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-12-06 DOI:10.1155/2012/386041
E M Brady, D R Webb, D H Morris, K Khunti, D S C Talbot, N Sattar, M J Davies
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引用次数: 11

摘要

目的:探讨居住在英国的南亚人(SA)和白种欧洲人(WE)在氧化应激和内皮活化测量方面的种族差异与已知心血管危险因素的关系。方法:来自英国多民族人群的202名参与者提供了生物医学和人体测量数据。定量测定人尿2,3-二-8-异前列腺素- f1 α和血浆ICAM-1分别作为氧化应激和内皮细胞活化的指标。结果:在调整年龄、性别、吸烟状况、体重、HbA1c和用药后,SA组2,3- dinor -8-iso-前列腺素- f1 α水平显著高于WE组(10.36 (95% CI: 9.09, 11.79)对8.46 (7.71,9.29),P = 0.021)。氧化应激与HbA1c (β = 1.08, 95% CI:1.02, 1.14, P = 0.009)、空腹(β = 1.06, 95% CI:1.02, 1.10, P = 0.002)和2小时血糖(β = 1.02, 95% CI: 1.00, 1.04, P = 0.052)呈正相关。在每个调整后的模型中,与WE相比,SA继续具有较高的氧化应激水平。与正常血糖组相比,复合IGR组的ICAM-1水平显著升高(P < 0.001)。ICAM-1未见种族差异。结论:低血糖阈值时SA比WE更容易受到高血糖诱导的氧化应激的不利影响。有必要进一步研究所涉及的潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating endothelial activation and oxidative stress in relation to glycaemic control in a multiethnic population.

Aim: An exploration of ethnic differences in measures of oxidative stress and endothelial activation in relation to known cardiovascular risk factors within South Asians (SA) and White Europeans (WE) residing in the UK.

Methods: 202 participants within a UK multiethnic population provided biomedical and anthropometric data. Human urinary 2,3-dinor-8-iso-prostaglandin-F1α and plasma ICAM-1 were quantified as measures of oxidative stress and endothelial activation, respectively.

Results: 2,3-Dinor-8-iso-prostaglandin-F1α levels were significantly higher in the SA group compared to WE group (10.36 (95% CI: 9.09, 11.79) versus 8.46 (7.71, 9.29), P = 0.021) after adjustment for age, gender, smoking status, body weight, HbA1c, and medication. Oxidative stress was positively associated with HbA1c (β = 1.08, 95% CI:1.02, 1.14, P = 0.009), fasting (β = 1.06, 95% CI: 1.02, 1.10, P = 0.002), and 2 hr glucose (β = 1.02, 95% CI: 1.00, 1.04, P = 0.052). In each adjusted model, SA continued to have elevated levels of oxidative stress compared to WE. ICAM-1 levels were significantly higher in the composite IGR group compared to the normoglycaemic group (P < 0.001). No ethnic differences in ICAM-1 were observed.

Conclusion: These results suggest that SA are more susceptible to the detrimental effects of hyperglycaemia-induced oxidative stress at lower blood glucose thresholds than WE. Further research into the potential mechanisms involved is warranted.

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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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