野癌标志物:前列腺活检的临床应用建议。

IF 2.3 Q3 ONCOLOGY

Prostate Cancer Pub Date : 2012-01-01 Epub Date: 2012-05-14 DOI:10.1155/2012/302894

Kristina A Trujillo, Anna C Jones, Jeffrey K Griffith, Marco Bisoffi

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引用次数: 54

摘要

野灶癌变是指癌灶附近组织学正常组织中结构完整的细胞发生遗传、表观遗传和生化畸变。本文列出了迄今为止已知的前列腺野癌标志物，并讨论了它们在前列腺活检分析中的潜在临床价值，包括诊断、主动监测过程中的监测进展、评估术前新辅助和局灶性治疗干预的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Markers of field cancerization: proposed clinical applications in prostate biopsies.

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Markers of field cancerization: proposed clinical applications in prostate biopsies.

Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.

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来源期刊

Prostate Cancer ONCOLOGY-

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.