{"title":"根据2004年世界卫生组织对非侵袭性尿路上皮肿瘤的分类MUC1 (Ma695)在非侵袭性乳头状尿路上皮肿瘤中的表达。病理学家的免疫工具?","authors":"Christian Garbar, Corinne Mascaux","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between MUC1 (Ma695) and noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification.</p><p><strong>Study design: </strong>Histologic evaluation was performed in 46 patients with nontumoral benign bladder urothelium (n = 11), papillary urothelial neoplasm of low malignant potential (PUNLMP) (n = 14), low-grade papillary urothelial carcinoma (LgPUC) (n = 11), and noninvasive high-grade papillary urothelial carcinoma (HgPUC) (n = 10). Classical morphologic description and semiquantitative digital measurement were performed from immunohistochemical-stained slides using an anti-MUC1 antibody (Ma695).</p><p><strong>Results: </strong>Measures showed an obvious statistical difference between benign urothelium and LgPUC (p = 0.0004) or HgPUC (p = 0.0041). MUC1 is expressed less in PUNLMP than in LgPUC (p = 0.04). Benign urothelium and PUNLMP more often showed apical and superficial MUC1 expression. Basal cells with cytoplasmic and/or circumferential membrane positivity were more often observed in LgPUC and HgPUC (p < 0.001).</p><p><strong>Conclusion: </strong>MUC1 could be an interesting tool for the pathologist to differentiate between PUNLMP and LgPUC or HgPUC.</p>","PeriodicalId":76995,"journal":{"name":"Analytical and quantitative cytology and histology","volume":"33 5","pages":"277-82"},"PeriodicalIF":0.0000,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression of MUC1 (Ma695) in noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification of the noninvasive urothelial neoplasm. An immunologic tool for the pathologist?\",\"authors\":\"Christian Garbar, Corinne Mascaux\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To examine the association between MUC1 (Ma695) and noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification.</p><p><strong>Study design: </strong>Histologic evaluation was performed in 46 patients with nontumoral benign bladder urothelium (n = 11), papillary urothelial neoplasm of low malignant potential (PUNLMP) (n = 14), low-grade papillary urothelial carcinoma (LgPUC) (n = 11), and noninvasive high-grade papillary urothelial carcinoma (HgPUC) (n = 10). Classical morphologic description and semiquantitative digital measurement were performed from immunohistochemical-stained slides using an anti-MUC1 antibody (Ma695).</p><p><strong>Results: </strong>Measures showed an obvious statistical difference between benign urothelium and LgPUC (p = 0.0004) or HgPUC (p = 0.0041). MUC1 is expressed less in PUNLMP than in LgPUC (p = 0.04). Benign urothelium and PUNLMP more often showed apical and superficial MUC1 expression. Basal cells with cytoplasmic and/or circumferential membrane positivity were more often observed in LgPUC and HgPUC (p < 0.001).</p><p><strong>Conclusion: </strong>MUC1 could be an interesting tool for the pathologist to differentiate between PUNLMP and LgPUC or HgPUC.</p>\",\"PeriodicalId\":76995,\"journal\":{\"name\":\"Analytical and quantitative cytology and histology\",\"volume\":\"33 5\",\"pages\":\"277-82\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical and quantitative cytology and histology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and quantitative cytology and histology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Expression of MUC1 (Ma695) in noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification of the noninvasive urothelial neoplasm. An immunologic tool for the pathologist?
Objective: To examine the association between MUC1 (Ma695) and noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification.
Study design: Histologic evaluation was performed in 46 patients with nontumoral benign bladder urothelium (n = 11), papillary urothelial neoplasm of low malignant potential (PUNLMP) (n = 14), low-grade papillary urothelial carcinoma (LgPUC) (n = 11), and noninvasive high-grade papillary urothelial carcinoma (HgPUC) (n = 10). Classical morphologic description and semiquantitative digital measurement were performed from immunohistochemical-stained slides using an anti-MUC1 antibody (Ma695).
Results: Measures showed an obvious statistical difference between benign urothelium and LgPUC (p = 0.0004) or HgPUC (p = 0.0041). MUC1 is expressed less in PUNLMP than in LgPUC (p = 0.04). Benign urothelium and PUNLMP more often showed apical and superficial MUC1 expression. Basal cells with cytoplasmic and/or circumferential membrane positivity were more often observed in LgPUC and HgPUC (p < 0.001).
Conclusion: MUC1 could be an interesting tool for the pathologist to differentiate between PUNLMP and LgPUC or HgPUC.
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