为什么要重新思考调节 TCR 行为的结构-功能关系？

Q4 Medicine

Current Trends in Immunology Pub Date : 2009-01-01

Melvin Cohn

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引用次数: 0

摘要

尽管人们普遍接受的 TCR（标准）模型为大量关键数据的积累提供了动力，但由于其基本原理--等位基因特异性识别 MHC 编码的限制性元件可通过对随机序列的体细胞选择而产生--的失败，该模型仍存在不足。标准模型因这一信条而受到的限制，以及对竞争模型可能的一瞥，使我们对 TCR 的结构-功能关系有了一个令人惊讶的新看法。本文将讨论一个已发表的实验，以说明这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Why rethink the structure-function relationships regulating TCR behavior?

Although the generally accepted (Standard) Model of the TCR has powered the accumulation of a large body of crucial data, it is lacking because of the failure of its basic tenet that allele-specific recognition of MHC-encoded restricting elements can be derived by somatic selection on a random repertoire. The limitations of the Standard Model due to this tenet and a glimpse at what a competing model might look like add up to yield a surprising new view of the structure-function relationships of the TCR. A published experiment illustrating this is discussed.

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来源期刊

Current Trends in Immunology Medicine-Immunology and Allergy

CiteScore

0.30

自引率

0.00%

发文量

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