微囊化哺乳动物细胞同时产生VEGF165b和IFNα。

Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2012-02-01 DOI:10.3109/10731199.2011.560120

Fatemeh Afkhami, Yves Durocher, Satya Prakash

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引用次数: 0

摘要

靶向和同时递送VEGF165b和IFN α在抗血管生成和其他应用中可以提供几个优势。为此，采用人工细胞海藻酸盐-聚l -赖氨酸-海藻酸盐(APA)微胶囊设计了一套系统。结果证实了该系统在28天内同时产生这些蛋白质的能力。IFN α在3 d内从第10天的8±0.36 μg/ml上升到第16天的27±2.4 μg/ml，然后下降到6.5±0.5 μg/ml。VEGF165b在3 d期间从第10天的2.7±0.7 μg/ml增加到第16天的6.9±1 μg/ml。

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Microencapsulated mammalian cells for simultaneous production of VEGF165b and IFNα.

Targeted and simultaneous delivery VEGF165b and IFN alpha in anti-angiogenic and other applications could offer several advantages. For this a system was design using artificial cell alginate-poly-L-lysine- alginate (APA) microcapsules. Result confirms the ability of this system for simultaneous production of these proteins for 28-days. The IFN alpha on a 3 days period increased from 8 ± 0.36 μg/ml at day 10 to 27 ± 2.4 μg/ml at day 16 and then dropped to 6.5 ± 0.5 μg/ml. The VEGF165b on a 3 days period increased from 2.7 ± 0.7 μg/ml at day 10 to 6.9 ± 1 μg/ml at day 16.

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来源期刊

Artificial cells, blood substitutes, and immobilization biotechnology 工程技术-材料科学：生物材料

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审稿时长

6-12 weeks