{"title":"分子细胞生物学能解释染色体运动吗?","authors":"Daniel H Shain, L John Gagliardi","doi":"10.1186/1742-4682-8-15","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mitotic chromosome motions have recently been correlated with electrostatic forces, but a lingering \"molecular cell biology\" paradigm persists, proposing binding and release proteins or molecular geometries for force generation.</p><p><strong>Results: </strong>Pole-facing kinetochore plates manifest positive charges and interact with negatively charged microtubule ends providing the motive force for poleward chromosome motions by classical electrostatics. This conceptual scheme explains dynamic tracking/coupling of kinetochores to microtubules and the simultaneous depolymerization of kinetochore microtubules as poleward force is generated.</p><p><strong>Conclusion: </strong>We question here why cells would prefer complex molecular mechanisms to move chromosomes when direct electrostatic interactions between known bound charge distributions can accomplish the same task much more simply.</p>","PeriodicalId":51195,"journal":{"name":"Theoretical Biology and Medical Modelling","volume":" ","pages":"15"},"PeriodicalIF":0.0000,"publicationDate":"2011-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1742-4682-8-15","citationCount":"3","resultStr":"{\"title\":\"Can molecular cell biology explain chromosome motions?\",\"authors\":\"Daniel H Shain, L John Gagliardi\",\"doi\":\"10.1186/1742-4682-8-15\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Mitotic chromosome motions have recently been correlated with electrostatic forces, but a lingering \\\"molecular cell biology\\\" paradigm persists, proposing binding and release proteins or molecular geometries for force generation.</p><p><strong>Results: </strong>Pole-facing kinetochore plates manifest positive charges and interact with negatively charged microtubule ends providing the motive force for poleward chromosome motions by classical electrostatics. This conceptual scheme explains dynamic tracking/coupling of kinetochores to microtubules and the simultaneous depolymerization of kinetochore microtubules as poleward force is generated.</p><p><strong>Conclusion: </strong>We question here why cells would prefer complex molecular mechanisms to move chromosomes when direct electrostatic interactions between known bound charge distributions can accomplish the same task much more simply.</p>\",\"PeriodicalId\":51195,\"journal\":{\"name\":\"Theoretical Biology and Medical Modelling\",\"volume\":\" \",\"pages\":\"15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/1742-4682-8-15\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Theoretical Biology and Medical Modelling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/1742-4682-8-15\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Mathematics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theoretical Biology and Medical Modelling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/1742-4682-8-15","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Mathematics","Score":null,"Total":0}
Can molecular cell biology explain chromosome motions?
Background: Mitotic chromosome motions have recently been correlated with electrostatic forces, but a lingering "molecular cell biology" paradigm persists, proposing binding and release proteins or molecular geometries for force generation.
Results: Pole-facing kinetochore plates manifest positive charges and interact with negatively charged microtubule ends providing the motive force for poleward chromosome motions by classical electrostatics. This conceptual scheme explains dynamic tracking/coupling of kinetochores to microtubules and the simultaneous depolymerization of kinetochore microtubules as poleward force is generated.
Conclusion: We question here why cells would prefer complex molecular mechanisms to move chromosomes when direct electrostatic interactions between known bound charge distributions can accomplish the same task much more simply.
期刊介绍：
Theoretical Biology and Medical Modelling is an open access peer-reviewed journal adopting a broad definition of "biology" and focusing on theoretical ideas and models associated with developments in biology and medicine. Mathematicians, biologists and clinicians of various specialisms, philosophers and historians of science are all contributing to the emergence of novel concepts in an age of systems biology, bioinformatics and computer modelling. This is the field in which Theoretical Biology and Medical Modelling operates. We welcome submissions that are technically sound and offering either improved understanding in biology and medicine or progress in theory or method.
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