Giuseppe Maiolino, Stefania Colonna, Mario Zanchetta, Luigi Pedon, Teresa Maria Seccia, Maurizio Cesari, Saula Vigili de Kreutzenberg, Angelo Avogaro, Gian Paolo Rossi
{"title":"肌细胞增强因子(MEF)2A外显子11缺失与西西里家族早发性冠状动脉疾病基因","authors":"Giuseppe Maiolino, Stefania Colonna, Mario Zanchetta, Luigi Pedon, Teresa Maria Seccia, Maurizio Cesari, Saula Vigili de Kreutzenberg, Angelo Avogaro, Gian Paolo Rossi","doi":"10.1177/1741826710397112","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>We investigated the prevalence of the myocyte enhancer factor (MEF)2A exon 11 deletion, a putative coronary artery disease (CAD) susceptibility gene, in patients referred for coronary angiography.</p><p><strong>Methods and results: </strong>In total, 1079 consecutive patients referred for coronary angiography in the GENICA Study were genotyped and 301 low-risk subjects were used as controls. One patient with early onset three vessels CAD, carrying the MEF2A deletion was found in the GENICA Study cohort and none in the control group.</p><p><strong>Conclusion: </strong>In a cohort of patients undergoing coronary angiography for suspected CAD the MEF2A exon 11 deletion occurred in 0.09%.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"18 4","pages":"557-60"},"PeriodicalIF":0.0000,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710397112","citationCount":"11","resultStr":"{\"title\":\"Exon 11 deletion in the myocyte enhancer factor (MEF)2A and early onset coronary artery disease gene in a Sicilian family.\",\"authors\":\"Giuseppe Maiolino, Stefania Colonna, Mario Zanchetta, Luigi Pedon, Teresa Maria Seccia, Maurizio Cesari, Saula Vigili de Kreutzenberg, Angelo Avogaro, Gian Paolo Rossi\",\"doi\":\"10.1177/1741826710397112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>We investigated the prevalence of the myocyte enhancer factor (MEF)2A exon 11 deletion, a putative coronary artery disease (CAD) susceptibility gene, in patients referred for coronary angiography.</p><p><strong>Methods and results: </strong>In total, 1079 consecutive patients referred for coronary angiography in the GENICA Study were genotyped and 301 low-risk subjects were used as controls. One patient with early onset three vessels CAD, carrying the MEF2A deletion was found in the GENICA Study cohort and none in the control group.</p><p><strong>Conclusion: </strong>In a cohort of patients undergoing coronary angiography for suspected CAD the MEF2A exon 11 deletion occurred in 0.09%.</p>\",\"PeriodicalId\":50492,\"journal\":{\"name\":\"European Journal of Cardiovascular Prevention & Rehabilitation\",\"volume\":\"18 4\",\"pages\":\"557-60\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/1741826710397112\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cardiovascular Prevention & Rehabilitation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/1741826710397112\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2011/3/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cardiovascular Prevention & Rehabilitation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1741826710397112","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/3/10 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Exon 11 deletion in the myocyte enhancer factor (MEF)2A and early onset coronary artery disease gene in a Sicilian family.
Aims: We investigated the prevalence of the myocyte enhancer factor (MEF)2A exon 11 deletion, a putative coronary artery disease (CAD) susceptibility gene, in patients referred for coronary angiography.
Methods and results: In total, 1079 consecutive patients referred for coronary angiography in the GENICA Study were genotyped and 301 low-risk subjects were used as controls. One patient with early onset three vessels CAD, carrying the MEF2A deletion was found in the GENICA Study cohort and none in the control group.
Conclusion: In a cohort of patients undergoing coronary angiography for suspected CAD the MEF2A exon 11 deletion occurred in 0.09%.
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