Johanna Meier, Thomas Becker, Anita Patel, Debbie Robson, Aart Schene, Martijn Kikkert, Corrado Barbui, Lorenzo Burti, Bernd Puschner
{"title":"精神分裂症患者药物相关因素对依从性的影响:一项欧洲多中心研究","authors":"Johanna Meier, Thomas Becker, Anita Patel, Debbie Robson, Aart Schene, Martijn Kikkert, Corrado Barbui, Lorenzo Burti, Bernd Puschner","doi":"10.1017/s1121189x00001184","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To investigate the relation between medication-related factors and adherence in people with schizophrenia in outpatient treatment.</p><p><strong>Methods: </strong>The sample comprised 409 outpatients (ICD-10 diagnosis of schizophrenia) with clinician-rated instability in four European cities (Amsterdam, The Netherlands; Verona, Italy; Leipzig, Germany; London, Great Britain). Adherence was assessed using the Medication Adherence Questionnaire (patient perspective), and the Clinician Rating Scale (clinician perspective). Examined medication-related factors were type (atypical vs. typical), application (oral vs. depot), daily dose frequency of antipsychotic medication (Medication History Scale), number of side effects (Liverpool University Neuroleptic Side Effect Rating Scale), and patient attitudes toward medication (Drug Attitude Inventory). Multiple regression analysis was used to identify predictors of adherence by medication-related factors.</p><p><strong>Results: </strong>Adherence, as rated by patient and clinician, was predicted by patient attitude towards medication, but was unrelated to type of drug, formulation or side effects of antipsychotic medication. A high daily dose frequency was associated with better adherence, but only when rated by the patient.</p><p><strong>Conclusions: </strong>In order to improve adherence there is a need to seriously consider and attempt to improve patient attitude toward medication. However, type of antipsychotic and other medication-related factors may not be as closely related to adherence as it has often been suggested.</p>","PeriodicalId":72946,"journal":{"name":"Epidemiologia e psichiatria sociale","volume":"19 3","pages":"251-9"},"PeriodicalIF":0.0000,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s1121189x00001184","citationCount":"24","resultStr":"{\"title\":\"Effect of medication-related factors on adherence in people with schizophrenia: a European multi-centre study.\",\"authors\":\"Johanna Meier, Thomas Becker, Anita Patel, Debbie Robson, Aart Schene, Martijn Kikkert, Corrado Barbui, Lorenzo Burti, Bernd Puschner\",\"doi\":\"10.1017/s1121189x00001184\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To investigate the relation between medication-related factors and adherence in people with schizophrenia in outpatient treatment.</p><p><strong>Methods: </strong>The sample comprised 409 outpatients (ICD-10 diagnosis of schizophrenia) with clinician-rated instability in four European cities (Amsterdam, The Netherlands; Verona, Italy; Leipzig, Germany; London, Great Britain). Adherence was assessed using the Medication Adherence Questionnaire (patient perspective), and the Clinician Rating Scale (clinician perspective). Examined medication-related factors were type (atypical vs. typical), application (oral vs. depot), daily dose frequency of antipsychotic medication (Medication History Scale), number of side effects (Liverpool University Neuroleptic Side Effect Rating Scale), and patient attitudes toward medication (Drug Attitude Inventory). Multiple regression analysis was used to identify predictors of adherence by medication-related factors.</p><p><strong>Results: </strong>Adherence, as rated by patient and clinician, was predicted by patient attitude towards medication, but was unrelated to type of drug, formulation or side effects of antipsychotic medication. A high daily dose frequency was associated with better adherence, but only when rated by the patient.</p><p><strong>Conclusions: </strong>In order to improve adherence there is a need to seriously consider and attempt to improve patient attitude toward medication. 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Effect of medication-related factors on adherence in people with schizophrenia: a European multi-centre study.
Aim: To investigate the relation between medication-related factors and adherence in people with schizophrenia in outpatient treatment.
Methods: The sample comprised 409 outpatients (ICD-10 diagnosis of schizophrenia) with clinician-rated instability in four European cities (Amsterdam, The Netherlands; Verona, Italy; Leipzig, Germany; London, Great Britain). Adherence was assessed using the Medication Adherence Questionnaire (patient perspective), and the Clinician Rating Scale (clinician perspective). Examined medication-related factors were type (atypical vs. typical), application (oral vs. depot), daily dose frequency of antipsychotic medication (Medication History Scale), number of side effects (Liverpool University Neuroleptic Side Effect Rating Scale), and patient attitudes toward medication (Drug Attitude Inventory). Multiple regression analysis was used to identify predictors of adherence by medication-related factors.
Results: Adherence, as rated by patient and clinician, was predicted by patient attitude towards medication, but was unrelated to type of drug, formulation or side effects of antipsychotic medication. A high daily dose frequency was associated with better adherence, but only when rated by the patient.
Conclusions: In order to improve adherence there is a need to seriously consider and attempt to improve patient attitude toward medication. However, type of antipsychotic and other medication-related factors may not be as closely related to adherence as it has often been suggested.