人类疾病的代谢组学分析及其在眼部的应用。

Stephen P Young, Graham R Wallace
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引用次数: 44

摘要

代谢组学是对体液或组织中代谢物谱的分析,目前正应用于对许多不同疾病的分析,并用于跟踪对治疗的反应。基因组学研究的是基因表达,蛋白质组学研究的是蛋白质表达,而代谢组学研究的是这些基因和蛋白质活性的结果。考虑到对感染和损伤的多层反应,我们有充分的理由认为代谢组学将在炎症研究中找到特别的用途。这可能与眼病特别相关,它可能具有组织特异性和系统性成分。代谢组学分析可以告诉我们有关眼部或其他体液的信息,因此可以提供有关这些反应的途径和过程的新信息。在这篇综述中,我们探讨了疾病的代谢后果,特别是眼部疾病,以及为什么使用代谢组学方法固有的多路分析可以有效和独特地评估数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolomic analysis of human disease and its application to the eye.

Metabolomics, the analysis of the metabolite profile in body fluids or tissues, is being applied to the analysis of a number of different diseases as well as being used in following responses to therapy. While genomics involves the study of gene expression and proteomics the expression of proteins, metabolomics investigates the consequences of the activity of these genes and proteins. There is good reason to think that metabolomics will find particular utility in the investigation of inflammation, given the multi-layered responses to infection and damage that are seen. This may be particularly relevant to eye disease, which may have tissue specific and systemic components. Metabolomic analysis can inform us about ocular or other body fluids and can therefore provide new information on pathways and processes involved in these responses. In this review, we explore the metabolic consequences of disease, in particular ocular conditions, and why the data may be usefully and uniquely assessed using the multiplexed analysis inherent in the metabolomic approach.

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