[阿尔茨海默病的流行病学:方法学方法和新观点]。

Claudine Berr, Marie-Noël Vercambre, Tasnime Nassime Akbaraly
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引用次数: 12

摘要

在过去的20年里,对阿尔茨海默病(AD)进行了大量的流行病学研究,为研究疾病频率提供了数据库,并对AD的危险因素进行了更全面的概述。然而,精确识别哪些因素增强或延迟疾病的病理过程仍然是不完整的。在基于人群的研究中,主要的问题之一是难以确定病例和获得良好的临床诊断。此外,无论研究的因素是什么,都很难确定暴露与疾病关系的年表:血管因素、生活习惯(饮食习惯、身体、社会或智力活动……)。哪个生命周期对于提出干预措施来改变这些因素是重要的,这仍然是一个核心问题。如果我们想在不久的将来有效地预防阿尔茨海默病,那么对大队列进行更长时间的随访和更好地了解潜在的风险因素是研究的重点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Epidemiology of Alzheimer's disease: methodological approaches and new perspectives].

Over the last 20 years, a number of epidemiological studies on Alzheimer's disease (AD) have been conducted on large cohorts providing databases for studying the disease frequency, and leading to a more global overview of AD risk factors. However, precise identification of factors which potentiate or delay the pathological process of the disease is still incomplete. One of the major problems comes from difficulties for defining the cases and obtaining good clinical diagnoses in population-based studies. Moreover, it is difficult to determine the chronology of exposure-disease relationships whatever the factors studied: vascular factors, life habits (dietary habits, physical, social or intellectual activities...). Which life-course period is important for proposing interventions to modify these factors remains a central question. The longer follow-up of large cohorts and a better knowledge of potential risk factors constitute a research priority if we want to prevent efficiently AD in the near future.

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