Sameed Ahmed M. Khatana BS, Tracey H. Taveira PharmD, Gaurav Choudhary MD, Charles B. Eaton MD, Wen-Chih Wu MD
{"title":"糖尿病患者血红蛋白A1c和c反应蛋白水平的变化","authors":"Sameed Ahmed M. Khatana BS, Tracey H. Taveira PharmD, Gaurav Choudhary MD, Charles B. Eaton MD, Wen-Chih Wu MD","doi":"10.1111/j.1559-4572.2008.00042.x","DOIUrl":null,"url":null,"abstract":"<p>The authors studied the effects on C-reactive protein (CRP) levels of an intensive intervention to reduce hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) among 58 veterans with type 2 diabetes. Weekly group sessions of behavioral and pharmacologic intervention were conducted for 4 weeks at Providence Veterans Affairs Medical Center. Change in cardiovascular risk factors and CRP levels were compared at baseline and 3 months postintervention. There was a significant decrease in HbA<sub>1c</sub> (−0.7%±1.9%, <i>P</i><.01), total cholesterol (−20.3±41.1 mg/dL, <i>P</i>=.01), low-density lipoprotein cholesterol (−11.7±31.4 mg/dL, <i>P</i>=.05), systolic blood pressure (−6.9±21.2 mm Hg, <i>P</i>=.03), and diastolic blood pressure (−6.0±10.6 mm Hg, <i>P</i><.01) over 4 months. There was no significant change in CRP levels (1.1±6.6 mg/L, <i>P</i>=.2). These results suggest that CRP effects may not be adequate to predict changes in cardiovascular risk among diabetic patients and should not be a surrogate for achieving evidence-based goals in traditional cardiovascular risk factors.</p>","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"4 2","pages":"76-80"},"PeriodicalIF":0.0000,"publicationDate":"2009-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1559-4572.2008.00042.x","citationCount":"4","resultStr":"{\"title\":\"Change in Hemoglobin A1c and C-Reactive Protein Levels in Patients With Diabetes Mellitus\",\"authors\":\"Sameed Ahmed M. Khatana BS, Tracey H. Taveira PharmD, Gaurav Choudhary MD, Charles B. Eaton MD, Wen-Chih Wu MD\",\"doi\":\"10.1111/j.1559-4572.2008.00042.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The authors studied the effects on C-reactive protein (CRP) levels of an intensive intervention to reduce hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) among 58 veterans with type 2 diabetes. Weekly group sessions of behavioral and pharmacologic intervention were conducted for 4 weeks at Providence Veterans Affairs Medical Center. Change in cardiovascular risk factors and CRP levels were compared at baseline and 3 months postintervention. There was a significant decrease in HbA<sub>1c</sub> (−0.7%±1.9%, <i>P</i><.01), total cholesterol (−20.3±41.1 mg/dL, <i>P</i>=.01), low-density lipoprotein cholesterol (−11.7±31.4 mg/dL, <i>P</i>=.05), systolic blood pressure (−6.9±21.2 mm Hg, <i>P</i>=.03), and diastolic blood pressure (−6.0±10.6 mm Hg, <i>P</i><.01) over 4 months. There was no significant change in CRP levels (1.1±6.6 mg/L, <i>P</i>=.2). These results suggest that CRP effects may not be adequate to predict changes in cardiovascular risk among diabetic patients and should not be a surrogate for achieving evidence-based goals in traditional cardiovascular risk factors.</p>\",\"PeriodicalId\":87477,\"journal\":{\"name\":\"Journal of the cardiometabolic syndrome\",\"volume\":\"4 2\",\"pages\":\"76-80\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-04-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1559-4572.2008.00042.x\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the cardiometabolic syndrome\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1559-4572.2008.00042.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the cardiometabolic syndrome","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1559-4572.2008.00042.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Change in Hemoglobin A1c and C-Reactive Protein Levels in Patients With Diabetes Mellitus
The authors studied the effects on C-reactive protein (CRP) levels of an intensive intervention to reduce hemoglobin A1c (HbA1c) among 58 veterans with type 2 diabetes. Weekly group sessions of behavioral and pharmacologic intervention were conducted for 4 weeks at Providence Veterans Affairs Medical Center. Change in cardiovascular risk factors and CRP levels were compared at baseline and 3 months postintervention. There was a significant decrease in HbA1c (−0.7%±1.9%, P<.01), total cholesterol (−20.3±41.1 mg/dL, P=.01), low-density lipoprotein cholesterol (−11.7±31.4 mg/dL, P=.05), systolic blood pressure (−6.9±21.2 mm Hg, P=.03), and diastolic blood pressure (−6.0±10.6 mm Hg, P<.01) over 4 months. There was no significant change in CRP levels (1.1±6.6 mg/L, P=.2). These results suggest that CRP effects may not be adequate to predict changes in cardiovascular risk among diabetic patients and should not be a surrogate for achieving evidence-based goals in traditional cardiovascular risk factors.
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