膝关节疼痛、半月板撕裂和骨关节炎患者的医疗决策。

Lisa G Suter, Liana Fraenkel, Elena Losina, Jeffrey N Katz, Andreas H Gomoll, A David Paltiel
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引用次数: 8

摘要

目的:半月板撕裂和骨关节炎(OA)经常共存,但据我们所知,没有数据表明谁将从关节镜半月板部分切除术(APM)和非手术治疗中获益。我们的目的是评估术前信息预测OA患者APM预后的能力。方法:使用数学模型和已发表的数据,我们将2个临床(机械症状和疼痛模式)和2个磁共振成像(撕裂类型和骨髓病变)指标合并为36个可能的组合,并根据45-65岁膝关节疼痛、OA和半月板撕裂患者主要发生撕裂或OA相关疼痛的可能性对每种组合进行排序。通过考虑实施APM的其他阈值,我们确定了使总体国际膝关节文献委员会(IKDC)评分(0-100分)最大化的截止等级。结果:1级(例如,撕裂移位,锁定,疼痛增加,无骨髓损伤)代表APM获益的可能性最高;36级(例如,斜撕裂,无机械症状,静态疼痛,严重骨髓损伤)代表APM获益的可能性最低。不确定的中间队列包括结果混合的个体(即,2个结果与APM获益可能性高一致,2个结果与APM获益可能性低一致)。排名17和23之间的APM阈值导致>82%的接受治疗的人群产生最大可能的IKDC改善,IKDC评分的平均增量收益>24分。研究结果在广泛的指标假设范围内都是稳健的,但对结果假设很敏感。结论:在患有退行性半月板撕裂和OA的个体中,容易获得的临床信息可以区分哪些更可能从APM中获益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis.

Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis.

Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis.

Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis.

Objective: Meniscal tears and osteoarthritis (OA) frequently coexist, but to our knowledge, no data exist to identify who will benefit from arthroscopic partial meniscectomy (APM) versus nonoperative management. Our objective was to evaluate the capability of preoperative information to predict APM outcomes in OA.

Methods: Using a mathematical model and published data, we combined 2 clinical (mechanical symptoms and pain pattern) and 2 magnetic resonance imaging (tear type and bone marrow lesions) indicators into 36 possible combinations and ranked each combination according to the likelihood of having primarily tear- versus OA-related pain in individuals ages 45-65 years with knee pain, OA, and meniscal tears. By considering alternative thresholds for performing APM, we identified the cutoff rank that maximized the overall population International Knee Documentation Committee (IKDC) score (0-100 scale).

Results: Rank 1 (e.g., displaced tear, locking, increased pain, no bone marrow lesions) represented the highest likelihood of APM benefit; rank 36 (e.g., oblique tear, no mechanical symptoms, static pain, severe bone marrow lesions) represented the lowest likelihood of APM benefit. Indeterminate middle ranks included individuals with mixed findings (i.e., 2 findings consistent with high and 2 with low likelihood of APM benefit). APM thresholds between ranks 17 and 23 resulted in >82% of the population receiving treatment producing the greatest possible IKDC improvement, with mean incremental gains in IKDC score of >24 points. Findings were robust across a broad range of indicator assumptions, but were sensitive to outcome assumptions.

Conclusion: Among individuals with degenerative meniscal tears and OA, easily obtainable clinical information can differentiate those who are more likely to benefit from APM.

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来源期刊
Arthritis and rheumatism
Arthritis and rheumatism 医学-风湿病学
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