{"title":"基于纳米二氧化钛/纳米碳纤维的电化学传感器用于生物样品中伊达柔比星的检测","authors":"Elham Arkan , Giti Paimard , Khalil Moradi","doi":"10.1016/j.jelechem.2017.08.034","DOIUrl":null,"url":null,"abstract":"<div><p>A novel electrochemical sensor based on a carbon paste electrode modified with electrospun carbon nanofibers and TiO<sub>2</sub> nanoparticles was prepared. It was designed to electrochemical determination of Idarubicin (IDA) in biological samples. To this end, carbon nanofibers were prepared by electrospinning process from polyacrylonitrile (PAN) and then modified with TiO<sub>2</sub> nanoparticles. Scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) techniques were employed for characterization of the various nanocomposite modified electrode. The results revealed that the modified electrodes showed an obvious electrocatalytic activity toward the oxidation of IDA by a remarkable enhancement in the current response compared with bare electrode. The modified electrode was applied to determine of IDA with square wave voltammetry (SWV) technique. Under optimized conditions, IDA gave a linear response in the concentration range of 0.012 to 10.0<!--> <!-->μM with the detection limit of 3<!--> <!-->nM. Interfering species of other anticancer drug such as doxorubicin, epirubicin and daunorubicin showed no interference with the selective determination of IDA. The finding suggests that the mentioned method was completely validated and successfully applied for the determination of IDA in real samples such as serum.</p></div>","PeriodicalId":355,"journal":{"name":"Journal of Electroanalytical Chemistry","volume":"801 ","pages":"Pages 480-487"},"PeriodicalIF":4.1000,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jelechem.2017.08.034","citationCount":"0","resultStr":"{\"title\":\"A novel electrochemical sensor based on electrospun TiO2 nanoparticles/carbon nanofibers for determination of Idarubicin in biological samples\",\"authors\":\"Elham Arkan , Giti Paimard , Khalil Moradi\",\"doi\":\"10.1016/j.jelechem.2017.08.034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A novel electrochemical sensor based on a carbon paste electrode modified with electrospun carbon nanofibers and TiO<sub>2</sub> nanoparticles was prepared. It was designed to electrochemical determination of Idarubicin (IDA) in biological samples. To this end, carbon nanofibers were prepared by electrospinning process from polyacrylonitrile (PAN) and then modified with TiO<sub>2</sub> nanoparticles. Scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) techniques were employed for characterization of the various nanocomposite modified electrode. The results revealed that the modified electrodes showed an obvious electrocatalytic activity toward the oxidation of IDA by a remarkable enhancement in the current response compared with bare electrode. The modified electrode was applied to determine of IDA with square wave voltammetry (SWV) technique. Under optimized conditions, IDA gave a linear response in the concentration range of 0.012 to 10.0<!--> <!-->μM with the detection limit of 3<!--> <!-->nM. Interfering species of other anticancer drug such as doxorubicin, epirubicin and daunorubicin showed no interference with the selective determination of IDA. The finding suggests that the mentioned method was completely validated and successfully applied for the determination of IDA in real samples such as serum.</p></div>\",\"PeriodicalId\":355,\"journal\":{\"name\":\"Journal of Electroanalytical Chemistry\",\"volume\":\"801 \",\"pages\":\"Pages 480-487\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2017-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jelechem.2017.08.034\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Electroanalytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1572665717305787\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Electroanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572665717305787","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
A novel electrochemical sensor based on electrospun TiO2 nanoparticles/carbon nanofibers for determination of Idarubicin in biological samples
A novel electrochemical sensor based on a carbon paste electrode modified with electrospun carbon nanofibers and TiO2 nanoparticles was prepared. It was designed to electrochemical determination of Idarubicin (IDA) in biological samples. To this end, carbon nanofibers were prepared by electrospinning process from polyacrylonitrile (PAN) and then modified with TiO2 nanoparticles. Scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) techniques were employed for characterization of the various nanocomposite modified electrode. The results revealed that the modified electrodes showed an obvious electrocatalytic activity toward the oxidation of IDA by a remarkable enhancement in the current response compared with bare electrode. The modified electrode was applied to determine of IDA with square wave voltammetry (SWV) technique. Under optimized conditions, IDA gave a linear response in the concentration range of 0.012 to 10.0 μM with the detection limit of 3 nM. Interfering species of other anticancer drug such as doxorubicin, epirubicin and daunorubicin showed no interference with the selective determination of IDA. The finding suggests that the mentioned method was completely validated and successfully applied for the determination of IDA in real samples such as serum.
期刊介绍：
The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied.
Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.
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