Myc的泛素化:蛋白酶体降解及其他。

J Müller, M Eilers
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引用次数: 22

摘要

Myc蛋白水平是细胞增殖和凋亡的关键决定因素。Myc的泛素化通过刺激蛋白质的蛋白酶体降解在控制蛋白质水平方面起关键作用。一些实验表明,泛素化可能也调节Myc的功能,除了周转。这篇综述试图总结当前关于这一领域的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ubiquitination of Myc: proteasomal degradation and beyond.

The level of Myc proteins is a critical determinant of cellular proliferation and apoptosis. Ubiquitination of Myc plays a key role in controlling protein levels by stimulating proteasomal degradation of the protein. Some experiments suggest that ubiquitination may also regulate Myc function in addition to turnover. This review attempts to summarize current knowledge about this field.

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