(边缘脑炎。误诊综合症]。

Stéphanie Cartalat-Carel, Natalia Leston, François Ducray, Véronique Rogemond, Jérôme Honnorat
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引用次数: 14

摘要

边缘脑炎(LE)患者表现出各种障碍,包括顺行性遗忘、情绪障碍(易怒、躁动或假性抑郁症状)和癫痫,通常是局部的,有时是全身性的,病程迅速进展。由于初始症状的可变性,边缘脑炎明显被误诊,经常误诊为病毒性脑炎。从病理生理学的角度来看,LE可分为两种类型。首先,LE与针对细胞内神经元抗原的抗体相关。它们与传统的副肿瘤性LE相对应,其特点是即使对病因肿瘤进行治疗,对治疗的反应也很弱。第二,LE与针对细胞膜抗原的抗体相关。这些LE可以是副肿瘤或特发性的,并且对免疫治疗有更好的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Limbic encephalitis. A misdiagnosed syndrome].

Patients with limbic encephalitis (LE) display various disorders including anterograde amnesia, mood disturbances (irritability, agitation or pseudo-depressive symptoms) and epilepsy, often partial but sometimes generalized, and rapidely progressive course. On account of the variability of the initial symptoms, limbic encephalitis is clearly under-diagnosed and often misdiagnosed as viral encephalitis. From a pathophysiological point of view, two types of LE can be identified. First, LE associated with antibodies directed against an intracellular neuronal antigen. They correspond to the traditional paraneoplastic LE, and are characterized by a weak response to treatment even when the causal tumor is treated. Second, LE associated with antibodies directed against antigens present on cellular membranes. These LE can be paraneoplastic or idiopathic, and present a better response to immunological treatments.

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