多发性硬化症患者及其一级亲属的自身免疫性疾病:丹麦的一项全国性队列研究

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2008-07-01 Epub Date: 2008-06-23 DOI:10.1177/1352458508088936

N M Nielsen, M Frisch, K Rostgaard, J Wohlfahrt, H Hjalgrim, N Koch-Henriksen, M Melbye, T Westergaard

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引用次数: 112

摘要

背景:多发性硬化症(MS)和其他自身免疫性疾病可能聚集在一起。我们的目的是在一项基于人群的队列研究中估计MS患者及其一级亲属中其他自身免疫性疾病的相对风险(RR)。方法:使用丹麦多发性硬化症登记册、丹麦医院出院登记册和丹麦民事登记系统，我们在以人群为基础的队列中估计了12 403名MS患者及其20 798名一级亲属的42种不同自身免疫性疾病的rr。根据国家性别、年龄和特定时期的发病率，观察到的自身免疫性疾病数量与预期数量的比率，作为rr的衡量标准。结果:与一般人群相比，MS患者发生溃疡性结肠炎(RR = 2.0(95%可信区间(CI): 1.4-2.8)， n = 29)和类天疱疮(RR = 15.4 (CI: 8.7-27.1)， n = 12)的风险增加，但类风湿关节炎(RR = 0.5 (CI: 0.4-0.8)， n = 28)和颞动脉炎(RR = 0.5 (CI: 0.3-0.97)， n = 11)的风险降低。MS患者一级亲属发生克罗恩病(RR = 1.4 (CI: 1.04-1.9)， n = 44)、溃疡性结肠炎(RR = 1.3 (CI: 0.99-1.7)， n = 51)、Addison's病(RR = 3.4 (CI: 1.3-9.0)， n = 4)、结节性多动脉炎(RR = 3.7 (CI: 1.4-10.0)， n = 4)的风险增加。结论:MS患者及其一级亲属发生某些自身免疫性疾病的风险增加。

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Autoimmune diseases in patients with multiple sclerosis and their first-degree relatives: a nationwide cohort study in Denmark.

Background: Multiple sclerosis (MS) and other autoimmune diseases might cluster. Our aim was to estimate the relative risk (RR) of other autoimmune diseases among MS patients and their first-degree relatives in a population-based cohort study.

Methods: Using the Danish Multiple Sclerosis Register, the Danish Hospital Discharge Register, and the Danish Civil Registration System, we estimated RRs for 42 different autoimmune diseases in a population-based cohort of 12 403 MS patients and 20 798 of their first-degree relatives. Ratios of observed to expected numbers of autoimmune diseases, based on national sex-, age-, and period-specific incidence rates, served as measures of the RRs.

Results: Compared with the general population, MS patients were at an increased risk of developing ulcerative colitis (RR = 2.0 (95% confidence interval (CI): 1.4-2.8), n = 29) and pemphigoid (RR = 15.4 (CI: 8.7-27.1), n = 12) but at reduced risk of rheumatoid arthritis (RR = 0.5 (CI: 0.4-0.8), n = 28) and temporal arteritis (RR = 0.5 (CI: 0.3-0.97), n = 11). First-degree relatives of MS patients were at increased risks of Crohn's disease (RR = 1.4 (CI: 1.04-1.9), n = 44), ulcerative colitis (RR = 1.3 (CI: 0.99-1.7), n = 51), Addison's disease (RR = 3.4 (CI: 1.3-9.0), n = 4), and polyarteritis nodosa (RR = 3.7 (CI: 1.4-10.0), n = 4).

Conclusion:

Patients: with MS and their first-degree relatives seem to be at an increased risk of acquiring certain other autoimmune diseases.

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585