{"title":"[甲状腺激素及其受体:小鼠遗传学是否阐明了这种情况?]。","authors":"Frédéric Flamant, Laure Quignodon","doi":"10.1051/jbio:2008008","DOIUrl":null,"url":null,"abstract":"<p><p>In vertebrates, the active form of thyroid hormone (T3) acts directly on transcription by changing the conformation of the TR nuclear receptors (TR alpha 1, TR beta 1 et TR beta 2) which are encoded by the THRA and THRB genes. These receptors are bound to DNA at specific response elements in a ligand independent manner. Mouse genetics have clarified the respective function of each receptor isoform, mainly reflecting THRA and THRB expression patterns. It also revealed the importance of negative regulation by unliganded receptors not only in pathological but also in physiological situations.</p>","PeriodicalId":80018,"journal":{"name":"Journal de la Societe de biologie","volume":"202 2","pages":"67-71"},"PeriodicalIF":0.0000,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1051/jbio:2008008","citationCount":"0","resultStr":"{\"title\":\"[Thyroid hormone and its receptors: have mouse genetics clarified the situation?].\",\"authors\":\"Frédéric Flamant, Laure Quignodon\",\"doi\":\"10.1051/jbio:2008008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In vertebrates, the active form of thyroid hormone (T3) acts directly on transcription by changing the conformation of the TR nuclear receptors (TR alpha 1, TR beta 1 et TR beta 2) which are encoded by the THRA and THRB genes. These receptors are bound to DNA at specific response elements in a ligand independent manner. Mouse genetics have clarified the respective function of each receptor isoform, mainly reflecting THRA and THRB expression patterns. It also revealed the importance of negative regulation by unliganded receptors not only in pathological but also in physiological situations.</p>\",\"PeriodicalId\":80018,\"journal\":{\"name\":\"Journal de la Societe de biologie\",\"volume\":\"202 2\",\"pages\":\"67-71\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1051/jbio:2008008\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal de la Societe de biologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1051/jbio:2008008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2008/6/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal de la Societe de biologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1051/jbio:2008008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2008/6/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
[Thyroid hormone and its receptors: have mouse genetics clarified the situation?].
In vertebrates, the active form of thyroid hormone (T3) acts directly on transcription by changing the conformation of the TR nuclear receptors (TR alpha 1, TR beta 1 et TR beta 2) which are encoded by the THRA and THRB genes. These receptors are bound to DNA at specific response elements in a ligand independent manner. Mouse genetics have clarified the respective function of each receptor isoform, mainly reflecting THRA and THRB expression patterns. It also revealed the importance of negative regulation by unliganded receptors not only in pathological but also in physiological situations.
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