PKC同型在T淋巴细胞中起作用。

G Baier
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引用次数: 9

摘要

成熟T细胞的主要功能是通过一个复杂的激活过程来识别和应答外来抗原,该过程包括静息细胞分化为增殖淋巴母细胞,积极分泌免疫调节淋巴因子或显示靶向细胞毒性,最终导致其他细胞类型的招募和有效免疫应答的启动。为了了解T淋巴细胞的生理和病理生理,有必要解码整合抗原、细胞因子、整合素和死亡受体信号的生化过程。我们的工作主要是基于探索和鉴定AGC蛋白丝氨酸/苏氨酸激酶家族不同成员的基因产物,这些基因产物是介导细胞生长调节的关键角色。鉴于PKC theta作为T细胞命运调节因子的重要作用,以及其他几种PKC同型也在T细胞中高水平表达,我们现在总结PKC α、β、δ、ε、ζ和θ同型在T细胞中的生理和非冗余功能。本文综述了目前对T细胞中PKC基因产物的生理和非冗余功能的了解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PKC isotype functions in T lymphocytes.

The main function of mature T cells is to recognize and respond to foreign antigens by a complex activation process involving differentiation of the resting cell to a proliferating lymphoblast actively secreting immunoregulatory lymphokines or displaying targeted cytotoxicity, ultimately leading to recruitment of other cell types and initiation of an effective immune response. In order to understand the physiology and pathophysiology of T lymphocytes, it is necessary to decode the biochemical processes that integrate signals from antigen, cytokine, integrin and death receptors. The principal upon which our work is based is to explore and identify gene products of distinct members of the AGC family of protein serine/threonine kinases as key players mediating cell growth regulation. Given the established important role of PKC theta as regulator of T cell fate and knowing that several other PKC isotypes are also expressed in T cells at a high level, we now summarize the physiological and non-redundant functions of PKC alpha, beta, delta, epsilon, zeta and theta isotypes in T cells. This review describes the current knowledge of the physiological and non-redundant functions of the PKC gene products in T cells.

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