Edmunds Lukevics, Edgars Abele, Pavel Arsenyan, Ramona Abele, Kira Rubina, Irina Shestakova, Ilona Domracheva, Violetta Vologdina
{"title":"含吡啶和喹啉硫化物硅的合成及其细胞毒性。","authors":"Edmunds Lukevics, Edgars Abele, Pavel Arsenyan, Ramona Abele, Kira Rubina, Irina Shestakova, Ilona Domracheva, Violetta Vologdina","doi":"10.1155/MBD.2002.45","DOIUrl":null,"url":null,"abstract":"<p><p>Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"9 1-2","pages":"45-51"},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2002.45","citationCount":"6","resultStr":"{\"title\":\"Synthesis and cytotoxicity of silicon containing pyridine and quinoline sulfides.\",\"authors\":\"Edmunds Lukevics, Edgars Abele, Pavel Arsenyan, Ramona Abele, Kira Rubina, Irina Shestakova, Ilona Domracheva, Violetta Vologdina\",\"doi\":\"10.1155/MBD.2002.45\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.</p>\",\"PeriodicalId\":18452,\"journal\":{\"name\":\"Metal-Based Drugs\",\"volume\":\"9 1-2\",\"pages\":\"45-51\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/MBD.2002.45\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Metal-Based Drugs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/MBD.2002.45\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metal-Based Drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/MBD.2002.45","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and cytotoxicity of silicon containing pyridine and quinoline sulfides.
Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.
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