在Ntra大学医院诊断的血红蛋白病。Sra。de Candelaria及其在圣克鲁斯de Tenerife的参考区域[一年]。

Anales De Medicina Interna Pub Date : 2008-02-01
S de las Heras Flórez, L M Pérez Hernández
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引用次数: 0

摘要

目的:描述我省一年内诊断出的血红蛋白病的数量和类型,以及这些患者的来源,以便首次接触到我省迄今未发现的这种病理。材料和方法:回顾一年内诊断出的所有血红蛋白病,无论是疑似患者,分析色谱定量血红蛋白(Hb) A1c或可疑-地中海贫血的血图。筛选方法采用高压液相色谱法(HPLC),对HbA2、HbS和HbC进行鉴定和定量。其他变异在参比实验室诊断。结果:诊断血红蛋白病变198例,检测HbA1c后确诊105例。更常见的诊断是-地中海贫血特征和杂合子HbS。61.1%的患者来自加那利群岛,主要来自特内里费岛。结论:从加那利群岛发现的大量携带者应作为设计人群群体前瞻性研究的起点,以便了解圣克鲁斯德特内里费省血红蛋白病的流行情况,并实施官方控制和预防方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Hemoglobinopathies diagnosed at the University Hospital Ntra. Sra. de Candelaria and its area of reference in Santa Cruz de Tenerife during one year].

Objective: To describe number and type of hemoglobinopathies diagnosed in our area of reference during one year as well as the origin of these patients, to have a first contact with this pathology not characterized in our province until now.

Material and method: All hemoglobinopathies diagnosed in one year were reviewed, either for suspected patients, after analyzing chromatogram to quantify hemoglobin (Hb) A1c or hemogram suspicious of beta-thalassemia. The screening method was high pressure liquid chromatography (HPLC), to identify and quantify HbA2, HbS and HbC. The other variants were diagnosed at reference laboratory.

Results: 198 hemoglobinopathies were diagnosed, 105 after measure HbA1c. The more frequent diagnoses were beta-thalassemia trait and heterozygote HbS. 61.1% of patients are from Canary Islands, mainly from Tenerife.

Conclusions: The high number of carriers found from Canary Islands, should be the start to design prospective studies on population groups, in order to know the hemoglobinopathies prevalence and to perform control and prevention official programs in the province of Santa Cruz de Tenerife.

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