Bonnie Spring, Jessica Werth Cook, Bradley Appelhans, Anne Maloney, Malia Richmond, Jocelyn Vaughn, Joseph Vanderveen, Donald Hedeker
{"title":"尼古丁对抑郁倾向吸烟者情感反应的影响。","authors":"Bonnie Spring, Jessica Werth Cook, Bradley Appelhans, Anne Maloney, Malia Richmond, Jocelyn Vaughn, Joseph Vanderveen, Donald Hedeker","doi":"10.1007/s00213-007-0977-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Rationale: </strong>Comorbidity between cigarette smoking and depression is thought to arise because depression-prone smokers self-administer nicotine to improve mood. Yet little evidence supports this view, and nicotine's effect on positive affect deficiency in depression remains largely unstudied.</p><p><strong>Objectives: </strong>We hypothesized that (1) nicotine would dispel negative affect and enhance positive affect and (2) effects would be stronger for smokers vulnerable to depression, particularly during a depressed state.</p><p><strong>Materials and methods: </strong>Regular smokers (N = 165) were recruited from the community: 63 with no history of major depressive disorder (MDD), 61 with recurrent past but no current MDD, and 41 with both current and past MDD. During four sessions, participants smoked either a nicotinized (NIC+) or denicotinized (NIC-) cigarette double blind after experiencing a negative mood induction or while undergoing a positive mood induction. Positive and negative affects were measured at baseline and at two time points after smoking.</p><p><strong>Results: </strong>Previously depressed smokers showed a heightened positive mood response to positive mood induction when smoking a nicotinized cigarette. Nicotine also increased the degree to which positive mood induction dispelled negative mood in depression-vulnerable smokers. Finally, nicotine worsened the negative affect response to negative mood induction for all groups.</p><p><strong>Conclusion: </strong>Self-administering nicotine appears to improve depression-prone smokers' emotional response to a pleasant stimulus.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":"196 3","pages":"461-71"},"PeriodicalIF":3.5000,"publicationDate":"2008-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00213-007-0977-7","citationCount":"67","resultStr":"{\"title\":\"Nicotine effects on affective response in depression-prone smokers.\",\"authors\":\"Bonnie Spring, Jessica Werth Cook, Bradley Appelhans, Anne Maloney, Malia Richmond, Jocelyn Vaughn, Joseph Vanderveen, Donald Hedeker\",\"doi\":\"10.1007/s00213-007-0977-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Rationale: </strong>Comorbidity between cigarette smoking and depression is thought to arise because depression-prone smokers self-administer nicotine to improve mood. Yet little evidence supports this view, and nicotine's effect on positive affect deficiency in depression remains largely unstudied.</p><p><strong>Objectives: </strong>We hypothesized that (1) nicotine would dispel negative affect and enhance positive affect and (2) effects would be stronger for smokers vulnerable to depression, particularly during a depressed state.</p><p><strong>Materials and methods: </strong>Regular smokers (N = 165) were recruited from the community: 63 with no history of major depressive disorder (MDD), 61 with recurrent past but no current MDD, and 41 with both current and past MDD. During four sessions, participants smoked either a nicotinized (NIC+) or denicotinized (NIC-) cigarette double blind after experiencing a negative mood induction or while undergoing a positive mood induction. Positive and negative affects were measured at baseline and at two time points after smoking.</p><p><strong>Results: </strong>Previously depressed smokers showed a heightened positive mood response to positive mood induction when smoking a nicotinized cigarette. Nicotine also increased the degree to which positive mood induction dispelled negative mood in depression-vulnerable smokers. Finally, nicotine worsened the negative affect response to negative mood induction for all groups.</p><p><strong>Conclusion: </strong>Self-administering nicotine appears to improve depression-prone smokers' emotional response to a pleasant stimulus.</p>\",\"PeriodicalId\":20783,\"journal\":{\"name\":\"Psychopharmacology\",\"volume\":\"196 3\",\"pages\":\"461-71\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2008-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s00213-007-0977-7\",\"citationCount\":\"67\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00213-007-0977-7\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2007/10/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00213-007-0977-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2007/10/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Nicotine effects on affective response in depression-prone smokers.
Rationale: Comorbidity between cigarette smoking and depression is thought to arise because depression-prone smokers self-administer nicotine to improve mood. Yet little evidence supports this view, and nicotine's effect on positive affect deficiency in depression remains largely unstudied.
Objectives: We hypothesized that (1) nicotine would dispel negative affect and enhance positive affect and (2) effects would be stronger for smokers vulnerable to depression, particularly during a depressed state.
Materials and methods: Regular smokers (N = 165) were recruited from the community: 63 with no history of major depressive disorder (MDD), 61 with recurrent past but no current MDD, and 41 with both current and past MDD. During four sessions, participants smoked either a nicotinized (NIC+) or denicotinized (NIC-) cigarette double blind after experiencing a negative mood induction or while undergoing a positive mood induction. Positive and negative affects were measured at baseline and at two time points after smoking.
Results: Previously depressed smokers showed a heightened positive mood response to positive mood induction when smoking a nicotinized cigarette. Nicotine also increased the degree to which positive mood induction dispelled negative mood in depression-vulnerable smokers. Finally, nicotine worsened the negative affect response to negative mood induction for all groups.
Conclusion: Self-administering nicotine appears to improve depression-prone smokers' emotional response to a pleasant stimulus.
期刊介绍：
Official Journal of the European Behavioural Pharmacology Society (EBPS)
Psychopharmacology is an international journal that covers the broad topic of elucidating mechanisms by which drugs affect behavior. The scope of the journal encompasses the following fields:
Human Psychopharmacology: Experimental
This section includes manuscripts describing the effects of drugs on mood, behavior, cognition and physiology in humans. The journal encourages submissions that involve brain imaging, genetics, neuroendocrinology, and developmental topics. Usually manuscripts in this section describe studies conducted under controlled conditions, but occasionally descriptive or observational studies are also considered.
Human Psychopharmacology: Clinical and Translational
This section comprises studies addressing the broad intersection of drugs and psychiatric illness. This includes not only clinical trials and studies of drug usage and metabolism, drug surveillance, and pharmacoepidemiology, but also work utilizing the entire range of clinically relevant methodologies, including neuroimaging, pharmacogenetics, cognitive science, biomarkers, and others. Work directed toward the translation of preclinical to clinical knowledge is especially encouraged. The key feature of submissions to this section is that they involve a focus on clinical aspects.
Preclinical psychopharmacology: Behavioral and Neural
This section considers reports on the effects of compounds with defined chemical structures on any aspect of behavior, in particular when correlated with neurochemical effects, in species other than humans. Manuscripts containing neuroscientific techniques in combination with behavior are welcome. We encourage reports of studies that provide insight into the mechanisms of drug action, at the behavioral and molecular levels.
Preclinical Psychopharmacology: Translational
This section considers manuscripts that enhance the confidence in a central mechanism that could be of therapeutic value for psychiatric or neurological patients, using disease-relevant preclinical models and tests, or that report on preclinical manipulations and challenges that have the potential to be translated to the clinic. Studies aiming at the refinement of preclinical models based upon clinical findings (back-translation) will also be considered. The journal particularly encourages submissions that integrate measures of target tissue exposure, activity on the molecular target and/or modulation of the targeted biochemical pathways.
Preclinical Psychopharmacology: Molecular, Genetic and Epigenetic
This section focuses on the molecular and cellular actions of neuropharmacological agents / drugs, and the identification / validation of drug targets affecting the CNS in health and disease. We particularly encourage studies that provide insight into the mechanisms of drug action at the molecular level. Manuscripts containing evidence for genetic or epigenetic effects on neurochemistry or behavior are welcome.
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