亚型选择性erα和erβ激动剂在心血管系统中的功能作用和分子机制。

P A Arias-Loza, V Jazbutyte, K H Fritzemeier, C Hegele-Hartung, L Neyses, G Ertl, T Pelzer
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引用次数: 3

摘要

心血管疾病发展中的性别差异提示雌激素在心脏病中的保护功能。激素替代疗法临床试验的负面或中性结果提供了明确的证据,表明女性性激素在心血管系统中的作用比以前认为的要复杂得多。特别是,如果不详细了解雌激素受体亚型在心脏和脉管系统中的具体功能,就无法了解雌激素的功能。本文综述了近年来在高血压、心肌肥厚和血管炎症的不同动物模型中,亚型选择性erα和erβ激动剂的研究进展。结果表明,特定内质网亚型的激活对高血压心脏病具有特异性和冗余的保护作用,最终可能转化为高血压心脏病的新治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional effects and molecular mechanisms of subtype-selective ERalpha and ERbeta agonists in the cardiovascular system.

Gender differences in the development of cardiovascular disease suggested for a protective function of estrogens in heart disease. The negative or neutral outcome of clinical trials on hormone replacement therapy provides clear evidence that the role of female sex hormones in the cardiovascular system is more complex than previously thought. In particular, the function of estrogens can not be understood without detailed knowledge on the specific function of both estrogen receptor subtypes in the heart and in the vasculature. In here, we review recent studies on subtype selective ERalpha and ERbeta agonists in different animal models of hypertension, cardiac hypertrophy and vascular inflammation. The results indicate that the activation of specific ER subtypes confers specific as well as redundant protective effects in hypertensive heart disease that might ultimately translate into novel treatment options for hypertensive heart disease.

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