先进仿生电极阵列在人耳蜗内位置的体内估计。

Margaret W Skinner, Timothy A Holden, Bruce R Whiting, Arne H Voie, Barry Brunsden, J Gail Neely, Eugene A Saxon, Timothy E Hullar, Charles C Finley
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引用次数: 0

摘要

目的:描述了一种确定耳蜗中每个电极位置的新技术,并将其应用于15例植入Advanced Bionics HiFocus I, Ij或Helix阵列的患者的螺旋计算机断层扫描数据。方法:采用ANALYZE成像软件对患者术前、术后扫描和临床扫描未植入耳的单个供体、显微计算机断层扫描和正交平面荧光光学切片(OPFOS)显微镜的三维图像体积进行配准。通过这种配准,我们将体供体耳蜗内软组织的OPFOS图像图谱与患者扫描数据中可用的骨和液/组织边界进行比较,选择中磨牙轴位置,判断电极在中耳膜或前庭鳞片中的位置,包括到内侧和外侧标量壁的距离。角旋转0度起始点为中磨牙轴与从前庭进入耳蜗道中间的一条线。结果:组内平均阵列插入深度为477°(范围286°~ 655°)。单词得分呈负相关(r = -0.59;P = 0.028),与前庭阶梯电极的数量有关。结论:尽管所有测量的个体差异很大,但在受试者中观察到重复的次优电极放置模式,强调了该技术的适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In vivo estimates of the position of advanced bionics electrode arrays in the human cochlea.

Objectives: A new technique for determining the position of each electrode in the cochlea is described and applied to spiral computed tomography data from 15 patients implanted with Advanced Bionics HiFocus I, Ij, or Helix arrays.

Methods: ANALYZE imaging software was used to register 3-dimensional image volumes from patients' preoperative and postoperative scans and from a single body donor whose unimplanted ears were scanned clinically, with micro computed tomography and with orthogonal-plane fluorescence optical sectioning (OPFOS) microscopy. By use of this registration, we compared the atlas of OPFOS images of soft tissue within the body donor's cochlea with the bone and fluid/ tissue boundary available in patient scan data to choose the midmodiolar axis position and judge the electrode position in the scala tympani or scala vestibuli, including the distance to the medial and lateral scalar walls. The angular rotation 0 degrees start point is a line joining the midmodiolar axis and the middle of the cochlear canal entry from the vestibule.

Results: The group mean array insertion depth was 477 degrees (range, 286 degrees to 655 degrees). The word scores were negatively correlated (r = -0.59; p = .028) with the number of electrodes in the scala vestibuli.

Conclusions: Although the individual variability in all measures was large, repeated patterns of suboptimal electrode placement were observed across subjects, underscoring the applicability of this technique.

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