Avima M Ruder, Martha A Waters, Mary Ann Butler, Tania Carreón, Geoffrey M Calvert, Karen E Davis-King, Paul A Schulte, Wayne T Sanderson, Elizabeth M Ward, L Barbara Connally, Ellen F Heineman, Jack S Mandel, Roscoe F Morton, Douglas J Reding, Kenneth D Rosenman, Glenn Talaska
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引用次数: 30
摘要
国家职业安全与健康研究所在一项研究中评估了农场农药暴露与胶质瘤风险的关系，该研究包括457例胶质瘤病例和648例以人群为基础的对照，所有成年男性(18-80岁)和爱荷华州、密歇根州、明尼苏达州和威斯康星州的非大都市居民。采用多元logistic回归控制农场居住地、年龄、年龄组、教育程度和其他农药暴露。没有发现胶质瘤与12种特定农药之间的关联。我们估计了调整后的优势比(OR)和95%置信区间(CI)，发现杀虫剂(OR = 0.53, CI = 0.37-0.77)、熏蒸剂(OR = 0.57, CI = 0.34-0.95)和有机氯(OR = 0.66, CI = 0.47-0.94)降低了胶质瘤的风险。在排除代理应答者(47%的病例)的分析中，大多数ci包括1.0。未发现农药暴露与胶质瘤呈正相关。其他农场暴露可能解释了先前研究中发现的脑癌风险过高的原因。
Gliomas and farm pesticide exposure in men: the upper midwest health study.
The National Institute for Occupational Safety and Health evaluated farm pesticide exposure and glioma risk in a study that included 457 glioma cases and 648 population-based controls, all adult men (18-80 yr old) and nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. Multiple logistic regressions were used to control for farm residence, age, age group, education, and exposure to other pesticides. No associations were found between glioma and 12 specific pesticides. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) and found reduced glioma risk for insecticides (OR = 0.53, CI = 0.37-0.77), fumigants (OR = 0.57, CI = 0.34-0.95), and organochlorines (OR = 0.66, CI = 0.47-0.94). In analyses excluding proxy respondents (47% of cases) most CIs included 1.0. No positive association of farm pesticide exposure and glioma was found. Other farm exposures may explain the excess brain cancer risk seen in previous studies.
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