河豚毒素中毒的临床特点及急救措施

Gui-zhen Liu, Jia-lin Che, Ming Xiao, Zuo-hua Fan
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引用次数: 0

摘要

目的:明确河豚毒素中毒的临床特点,探讨河豚毒素中毒的急救措施。方法:回顾性分析33例河豚毒素中毒的急救措施及救治结果。结果:这些患者在给予阿托品或应用呼吸刺激剂后均无明显效果,但实施机械通气和综合生命支持措施后,轻中度患者在10 ~ 14 h内抢救成功,危重患者在19 ~ 24 h内恢复自主呼吸。河豚毒素选择性地阻断神经肌肉电活动,产生非去极化曲线的效果,导致呼吸驱动的失败而不损害呼吸中枢。阿托品、m -胆碱能受体阻滞剂或中枢兴奋剂可能效果不明显,但包括维持有效通气在内的综合治疗可取得满意效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Clinical nature of tetrodotoxin intoxication and the measures for emergency rescue].

Objective: To define the clinical nature of tetrodotoxin intoxication and explore the measures for its emergency rescue.

Methods: The emergency rescue measures and outcomes of 33 cases tetrodotoxin intoxication were reviewed.

Results: No obvious effects were observed in these patients after administration of atropine or application of respiratory stimulant, but implementation of mechanical ventilation and comprehensive life support measures resulted in successful rescue of mild to moderate cases within 10 to 14 h, and recovery of spontaneous respiration was achieved in critical cases in 19-24 h.

Conclusion: Tetrodotoxin selectively blocks the neuromuscular electrical activity, producing the effect of nondepolarizing curine and leading to failure of the respiratory drive without compromising the respiratory center. Atropine, a M-cholinergic receptor blocker, or central stimulants may fail to produce obvious effects, but comprehensive treatments including maintenance of effective ventilation can bring satisfactory effects.

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