骨密度测试是否适用于所有绝经期妇女?

Michael Kleerekoper, Dorothy A Nelson
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引用次数: 0

摘要

美国预防服务工作组提供了一个基于证据的指南,表明骨密度(BMD)测试适用于所有65岁或以上的女性。这并不排除在年轻的绝经后妇女中进行骨密度测试,但将责任放在治疗医生身上,向患者和患者的保险公司证明该程序的合理性。很少有情况适合健康的绝经前妇女进行骨密度测试,但对年轻的绝经后妇女进行骨密度测试通常是合适的:当有骨质疏松症合并骨折的家族史,成年后有个人骨折史,以及可能与骨质流失加速或骨折风险增加有关的医疗、手术或治疗史。医疗条件包括与吸收不良相关的肠道疾病,如非热带口疮或原发性甲状旁腺功能亢进。患有增加跌倒风险的神经系统疾病的女性也应该进行测试。有数据表明,患有血红蛋白病的患者患骨质疏松症的风险增加。手术条件包括越来越多的肥胖手术和其他导致肠切除术的手术(例如,炎症性肠病)。与药物相关的主要问题是皮质类固醇治疗,但慢性或过度使用甲状腺素和慢性肝素治疗也应被视为骨质疏松症的危险因素。当第一次做骨密度测试时,有必要记住50%的绝经妇女会有负的t评分,但这并不意味着患者确实从她的峰值骨量中失去了任何骨头。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is BMD testing appropriate for all menopausal women?

The United States Preventive Services Task Force has provided an evidence-based guideline indicating that bone mineral density (BMD) testing is appropriate for all women aged 65 or older. This does not preclude BMD testing in younger postmenopausal women but places the onus on the treating physician to justify the procedure to the patient and often the patient's insurance carrier. There are very few circumstances in which BMD testing is appropriate for healthy premenopausal women, but BMD testing in younger postmenopausal women is often appropriate: when there is a family history of osteoporosis with fracture, a personal history of fracture as an adult, and a medical, surgical or therapeutic history that might be associated with accelerated bone loss or increased risk of fracture. Medical conditions include intestinal diseases associated with malabsorption, such as non-tropical sprue, or primary hyperparathyroidism. Women who have neurologic conditions that increase the risk of falling should also be tested. There are data to suggest that patients with hemoglobinopathy are at increased risk for osteoporosis. Surgical conditions include the increasingly performed surgery for obesity and other surgery resulting in bowel resection (e.g., for inflammatory bowel disease). The major medication-related concern is corticosteroid therapy, but chronic or over-treatment with thyroxine, and chronic heparin therapy, should also be considered risk factors for osteoporosis. When performing a BMD test for the first time, it is essential to remember that 50% of women at menopause will have a negative T-score, but this does not imply that the patient has indeed lost any bone from her peak bone mass.

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