黄顶孢ATCC 48272产头孢菌素C的菌种改良研究。

Hindustan antibiotics bulletin Pub Date : 2003-02-01

P Ellaiah, J Prem Kumar, V Saisha, J J Sumitra, P Vaishali

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摘要

抗生素生产的菌株开发是高效生产过程的必要前提。以紫外光和n -甲基- n1 -硝基-亚硝基胍(NTG)为诱变剂，进行了高产菌株的研究。产生的突变体PNTG-22的产率是亲本的2.4倍(810-1995 μ g/ml)。

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Strain improvement studies on production of cephalosporin C from Acremonium chrysogenum ATCC 48272.

Strain development for antibiotic production has been an essential prerequistie for efficient production process. Studies were carried out to produce high antibiotic yield strain by using UV and N-methyl-N1-nitro-nitrosoguanidine (NTG) as mutagens. A superior mutant (PNTG-22) with a productivity of 2.4 time (810-1995 microg/ml higher than, the parent strain was produced.

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Hindustan antibiotics bulletin

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