omega-3脂肪酸的膜调节作用:分子水平相互作用的分析。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology
Current topics in membranes Pub Date : 2020-01-01 Epub Date: 2020-09-14 DOI:10.1016/bs.ctm.2020.08.001
Manuela A A Ayee, Brendan C Bunker, Jordan L De Groot
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引用次数: 4

摘要

生物活性的omega-3多不饱和脂肪酸已被证明可以降低心血管疾病患者的死亡风险,并减轻其他炎症性疾病的症状。然而,这些效应的作用机制尚不清楚。据推测,omega-3多不饱和脂肪酸通过掺入细胞膜并改变细胞受体的信号特性来修饰细胞膜。在本章中,我们探讨了omega-3多不饱和脂肪酸对细胞膜结构和功能的影响。我们回顾了目前这些化合物对健康有益的证据,并探讨了omega-3多不饱和脂肪酸与膜脂相互作用并调节双层结构的分子机制。利用多组分磷脂双层的计算模型,我们评估了这些脂肪酸的掺入对膜脂堆积、水渗透和膜结构的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Membrane modulatory effects of omega-3 fatty acids: Analysis of molecular level interactions.

Bioactive omega-3 polyunsaturated fatty acids have been shown to reduce the risk of death in patients with cardiovascular disease and alleviate the symptoms of other inflammatory diseases. However, the mechanisms of action of these effects remain unclear. It has been postulated that omega-3 polyunsaturated fatty acids modify cell membranes by incorporation into the membrane and altering the signaling properties of cellular receptors. In this chapter, we explore the effects of omega-3 polyunsaturated fatty acids on cell membrane structure and function. We present a review of the current evidence for the health benefits of these compounds and explore the molecular mechanisms through which omega-3 polyunsaturated fatty acids interact with membrane lipids and modulate bilayer structure. Using computational models of multicomponent phospholipid bilayers, we assess the consequences of incorporation of these fatty acids on membrane lipid packing, water permeation, and membrane structure.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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