免疫代谢:树突状细胞功能的桥梁。

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-04-01 DOI:10.1080/08830185.2021.1897124
Yuting Sun, Liyu Zhou, Weikai Chen, Linhui Zhang, Hongbo Zeng, Yunxia Sun, Jun Long, Dongping Yuan
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引用次数: 6

摘要

越来越多的研究表明,细胞代谢调节细胞功能。树突状细胞(dc)是一种专业的抗原呈递细胞,连接先天免疫应答和适应性免疫应答。dc对糖或脂质的偏好影响其表型和功能。在动脉粥样硬化(as)、糖尿病、肿瘤等多种疾病中,微环境中葡萄糖或脂质水平的改变使dc发挥无效或相反的免疫作用,从而加速了这些疾病的发展。本文就葡萄糖和胆固醇在dc中的代谢途径以及代谢变化对dc表型和功能的影响进行综述。此外,我们还讨论了不同疾病背景下葡萄糖和脂质水平变化对dc的影响,以便更好地了解dc与疾病之间的关系。dc的免疫代谢可能是治疗代谢相关免疫疾病的潜在干预环节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immune metabolism: a bridge of dendritic cells function.

An increasing number of researches have shown that cell metabolism regulates cell function. Dendritic cells (DCs), a professional antigen presenting cells, connect innate and adaptive immune responses. The preference of DCs for sugar or lipid affects its phenotypes and functions. In many diseases such as atherosclerosis (AS), diabetes mellitus and tumor, altered glucose or lipid level in microenvironment makes DCs exert ineffective or opposite immune roles, which accelerates the development of these diseases. In this article, we review the metabolism pathways of glucose and cholesterol in DCs, and the effects of metabolic changes on the phenotype and function of DCs. In addition, we discuss the effects of changes in glucose and lipid levels on DCs in the context of different diseases for better understanding the relationship between DCs and diseases. The immune metabolism of DCs may be a potential intervention link to treat metabolic-related immune diseases.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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