SARS-CoV-2基因组浏览的新视角

IF 1.5 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Visam Gültekin, Jens Allmer
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引用次数: 2

摘要

SARS-CoV-2已在全球传播,并造成社会、经济和卫生动荡。首个SARS-CoV-2基因组组装体是在武汉产生的,具有广泛的参考价值。随后,又对100多个SARS-CoV-2基因组进行了测序。虽然基因组看起来基本相同,但也存在差异。因此,所有可用的基因组比对和衍生的共识序列可以作为参考,更好地服务于科学界。变异是很重要的,但在基因组浏览器中表示它们可能会变得很困难,特别是如果它们的序列在很大程度上是相同的。在这里,我们总结一个轨道的变化。目前在SARS-CoV-2基因组浏览器中未发现的其他信息,如预测的mirna和预测的TRS以及二级结构信息,也被添加到共识基因组中。我们认为,基于共识序列的基因组浏览器更适合考虑全球影响,可以成为抗击COVID-19的宝贵资源。基因组浏览器可在http://cov.iaba.online上获得。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Novel perspectives for SARS-CoV-2 genome browsing.

Novel perspectives for SARS-CoV-2 genome browsing.

Novel perspectives for SARS-CoV-2 genome browsing.

Novel perspectives for SARS-CoV-2 genome browsing.

SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mostly identical, there are variations. Therefore, an alignment of all available genomes and the derived consensus sequence could be used as a reference, better serving the science community. Variations are significant, but representing them in a genome browser can become, especially if their sequences are largely identical. Here we summarize the variation in one track. Other information not currently found in genome browsers for SARS-CoV-2, such as predicted miRNAs and predicted TRS as well as secondary structure information, were also added as tracks to the consensus genome. We believe that a genome browser based on the consensus sequence is better suited when considering worldwide effects and can become a valuable resource in the combating of COVID-19. The genome browser is available at http://cov.iaba.online.

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来源期刊
Journal of Integrative Bioinformatics
Journal of Integrative Bioinformatics Medicine-Medicine (all)
CiteScore
3.10
自引率
5.30%
发文量
27
审稿时长
12 weeks
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