Mesut Ozturk, Ahmet Veysel Polat, Fevziye Canbaz Tosun, Mustafa Bekir Selcuk
{"title":"FDG-PET/CT的SUVmax与肌肉骨骼恶性肿瘤DWI的ADC值是否相关?","authors":"Mesut Ozturk, Ahmet Veysel Polat, Fevziye Canbaz Tosun, Mustafa Bekir Selcuk","doi":"10.5334/jbsr.2378","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the correlation of maximum standardized uptake values (SUV<sub>max</sub>) of <sup>18</sup>F-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) with the apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) in musculoskeletal malignancies.</p><p><strong>Methods: </strong>Institutional ethics committee approved this retrospective study. Twenty-seven patients (mean age: 44.85 ± 24.07; 17 men and 10 women) with a total of 29 musculoskeletal tumors underwent both FDG-PET/CT and DWI between January 2017 and March 2020. Region-of-interest (ROI)-based maximal standardized uptake values (SUV<sub>max</sub>) of the tumors were measured on FDG-PET/CT images. Two radiologists measured lesions' mean and minimum apparent diffusion coefficient (ADC<sub>mean</sub> and ADC<sub>min</sub>) using five distinct ROIs on DWI images. Pearson correlation analysis was used to assess the correlation between SUV<sub>max</sub> and ADC values.</p><p><strong>Results: </strong>There were 18 soft tissue tumors (62.1%) and 11 bone tumors (37.9%) with a mean maximum diameter of 9.4 ± 6.2 cm. The mean SUV<sub>max</sub>, ADC<sub>mean</sub> and ADC<sub>min</sub> of the whole lesions were 12.93 ± 9.63, 0.85 ± 0.28 × 10<sup>-3</sup>mm<sup>2</sup>/s and 0.61 ± 0.27 × 10<sup>-3</sup>mm<sup>2</sup>/s, respectively. SUV<sub>max</sub> had a weak correlation with tumor maximum diameter (r = 0.378, p = 0.043), whereas ADC<sub>mean</sub> and ADC<sub>min</sub> had none. There was strong inverse correlation between SUV<sub>max</sub> and both ADC<sub>mean</sub> (r = -0.616, p < 0.001) and ADC<sub>min</sub> (r = -0.638, p < 0.001).</p><p><strong>Conclusion: </strong>In musculoskeletal tumors, quantitative markers of FDG uptake and diffusion restriction strongly correlate.</p>","PeriodicalId":56282,"journal":{"name":"Journal of the Belgian Society of Radiology","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908928/pdf/","citationCount":"1","resultStr":"{\"title\":\"Does the SUVmax of FDG-PET/CT Correlate with the ADC Values of DWI in Musculoskeletal Malignancies?\",\"authors\":\"Mesut Ozturk, Ahmet Veysel Polat, Fevziye Canbaz Tosun, Mustafa Bekir Selcuk\",\"doi\":\"10.5334/jbsr.2378\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the correlation of maximum standardized uptake values (SUV<sub>max</sub>) of <sup>18</sup>F-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) with the apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) in musculoskeletal malignancies.</p><p><strong>Methods: </strong>Institutional ethics committee approved this retrospective study. Twenty-seven patients (mean age: 44.85 ± 24.07; 17 men and 10 women) with a total of 29 musculoskeletal tumors underwent both FDG-PET/CT and DWI between January 2017 and March 2020. Region-of-interest (ROI)-based maximal standardized uptake values (SUV<sub>max</sub>) of the tumors were measured on FDG-PET/CT images. Two radiologists measured lesions' mean and minimum apparent diffusion coefficient (ADC<sub>mean</sub> and ADC<sub>min</sub>) using five distinct ROIs on DWI images. Pearson correlation analysis was used to assess the correlation between SUV<sub>max</sub> and ADC values.</p><p><strong>Results: </strong>There were 18 soft tissue tumors (62.1%) and 11 bone tumors (37.9%) with a mean maximum diameter of 9.4 ± 6.2 cm. The mean SUV<sub>max</sub>, ADC<sub>mean</sub> and ADC<sub>min</sub> of the whole lesions were 12.93 ± 9.63, 0.85 ± 0.28 × 10<sup>-3</sup>mm<sup>2</sup>/s and 0.61 ± 0.27 × 10<sup>-3</sup>mm<sup>2</sup>/s, respectively. SUV<sub>max</sub> had a weak correlation with tumor maximum diameter (r = 0.378, p = 0.043), whereas ADC<sub>mean</sub> and ADC<sub>min</sub> had none. There was strong inverse correlation between SUV<sub>max</sub> and both ADC<sub>mean</sub> (r = -0.616, p < 0.001) and ADC<sub>min</sub> (r = -0.638, p < 0.001).</p><p><strong>Conclusion: </strong>In musculoskeletal tumors, quantitative markers of FDG uptake and diffusion restriction strongly correlate.</p>\",\"PeriodicalId\":56282,\"journal\":{\"name\":\"Journal of the Belgian Society of Radiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2021-02-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908928/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Belgian Society of Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5334/jbsr.2378\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Belgian Society of Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5334/jbsr.2378","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
摘要
目的:评价18f -氟氧葡萄糖-正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)的最大标准化摄取值(SUVmax)与肌肉骨骼恶性肿瘤弥散加权成像(DWI)的表观扩散系数(ADC)的相关性。方法:机构伦理委员会批准本回顾性研究。27例，平均年龄44.85±24.07;2017年1月至2020年3月期间，17名男性和10名女性共29例肌肉骨骼肿瘤接受了FDG-PET/CT和DWI检查。在FDG-PET/CT图像上测量肿瘤基于感兴趣区域(ROI)的最大标准化摄取值(SUVmax)。两名放射科医生使用DWI图像上的五个不同roi测量病变的平均和最小表观扩散系数(ADCmean和ADCmin)。采用Pearson相关分析评估SUVmax与ADC值的相关性。结果:软组织肿瘤18例(62.1%)，骨肿瘤11例(37.9%)，平均最大直径9.4±6.2 cm。整个病变的平均SUVmax、ADCmean和ADCmin分别为12.93±9.63、0.85±0.28 × 10-3mm2/s和0.61±0.27 × 10-3mm2/s。SUVmax与肿瘤最大直径呈弱相关(r = 0.378, p = 0.043)，而ADCmean和ADCmin无相关性。SUVmax与ADCmean (r = -0.616, p < 0.001)和ADCmin (r = -0.638, p < 0.001)呈极显著负相关。结论:在肌肉骨骼肿瘤中，FDG摄取和扩散限制的定量标记有很强的相关性。
Does the SUVmax of FDG-PET/CT Correlate with the ADC Values of DWI in Musculoskeletal Malignancies?
Purpose: To evaluate the correlation of maximum standardized uptake values (SUVmax) of 18F-Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) with the apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) in musculoskeletal malignancies.
Methods: Institutional ethics committee approved this retrospective study. Twenty-seven patients (mean age: 44.85 ± 24.07; 17 men and 10 women) with a total of 29 musculoskeletal tumors underwent both FDG-PET/CT and DWI between January 2017 and March 2020. Region-of-interest (ROI)-based maximal standardized uptake values (SUVmax) of the tumors were measured on FDG-PET/CT images. Two radiologists measured lesions' mean and minimum apparent diffusion coefficient (ADCmean and ADCmin) using five distinct ROIs on DWI images. Pearson correlation analysis was used to assess the correlation between SUVmax and ADC values.
Results: There were 18 soft tissue tumors (62.1%) and 11 bone tumors (37.9%) with a mean maximum diameter of 9.4 ± 6.2 cm. The mean SUVmax, ADCmean and ADCmin of the whole lesions were 12.93 ± 9.63, 0.85 ± 0.28 × 10-3mm2/s and 0.61 ± 0.27 × 10-3mm2/s, respectively. SUVmax had a weak correlation with tumor maximum diameter (r = 0.378, p = 0.043), whereas ADCmean and ADCmin had none. There was strong inverse correlation between SUVmax and both ADCmean (r = -0.616, p < 0.001) and ADCmin (r = -0.638, p < 0.001).
Conclusion: In musculoskeletal tumors, quantitative markers of FDG uptake and diffusion restriction strongly correlate.
期刊介绍：
The purpose of the Journal of the Belgian Society of Radiology is the publication of articles dealing with diagnostic and interventional radiology, related imaging techniques, allied sciences, and continuing education.
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