{"title":"胃肠道恶性肿瘤诊断与治疗的计算方法。","authors":"Rama Rao Malla, Deepthi Nammi","doi":"10.1615/CritRevOncog.2020036436","DOIUrl":null,"url":null,"abstract":"<p><p>The major challenging problem in the world is cancer. It is a complex disease. Somatic mutations in the genome cause genetic changes and lead to initiation and promotion of tumor growth. Many researchers are working to identify cancer driver mutations using traditional approaches. In combination with traditional approaches, computational approaches provide a new insight for novel therapeutic options in oncology. In order to address this problem, there is a need to implement computational approaches like genomics, proteomics, and metabolomics to overcome the problem with less time for accurate results. This review discusses one computational method: genome-wide association studies for identifying SNPs in colon, gastrointestinal, esophageal, and pancreatic cancers.</p>","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Computational Approaches for Diagnosis and Therapy of GI Malignancies.\",\"authors\":\"Rama Rao Malla, Deepthi Nammi\",\"doi\":\"10.1615/CritRevOncog.2020036436\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The major challenging problem in the world is cancer. It is a complex disease. Somatic mutations in the genome cause genetic changes and lead to initiation and promotion of tumor growth. Many researchers are working to identify cancer driver mutations using traditional approaches. In combination with traditional approaches, computational approaches provide a new insight for novel therapeutic options in oncology. In order to address this problem, there is a need to implement computational approaches like genomics, proteomics, and metabolomics to overcome the problem with less time for accurate results. This review discusses one computational method: genome-wide association studies for identifying SNPs in colon, gastrointestinal, esophageal, and pancreatic cancers.</p>\",\"PeriodicalId\":35617,\"journal\":{\"name\":\"Critical Reviews in Oncogenesis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical Reviews in Oncogenesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1615/CritRevOncog.2020036436\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Oncogenesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1615/CritRevOncog.2020036436","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Computational Approaches for Diagnosis and Therapy of GI Malignancies.
The major challenging problem in the world is cancer. It is a complex disease. Somatic mutations in the genome cause genetic changes and lead to initiation and promotion of tumor growth. Many researchers are working to identify cancer driver mutations using traditional approaches. In combination with traditional approaches, computational approaches provide a new insight for novel therapeutic options in oncology. In order to address this problem, there is a need to implement computational approaches like genomics, proteomics, and metabolomics to overcome the problem with less time for accurate results. This review discusses one computational method: genome-wide association studies for identifying SNPs in colon, gastrointestinal, esophageal, and pancreatic cancers.
期刊介绍:
The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.