Jeroen Desmet, Charlotte Biebaû, Walter De Wever, Lesley Cockmartin, Verbraeken Viktor, Johan Coolen, Johny Verschakelen, Adriana Dubbeldam
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Comparative analysis of the 199 COVID-19 positive versus 411 COVID-19 negative patients was done with identification of risk factors and predictors of worse outcome.</p><p><strong>Results: </strong>Sensitivity and specificity of low-dose CT for the diagnosis of COVID-19 respectively ranged from 75% (150/199) to 88% (175/199) and 94% (386/411) to 99% (386/389), depending on the inclusion of inconclusive results. On multivariate analysis, a higher body mass index (BMI), fever, and dyspnea on admission were risk factors for COVID-19 (all p-values < 0.05). The mortality rate was 12.6% (25/199). Higher age and high levels of C-reactive protein (CRP) and D-dimers were predictors of worse outcome (all p-values < 0.05).</p><p><strong>Conclusion: </strong>Low-dose chest CT has a high specificity and a moderate to high sensitivity in symptomatic patients with suspicion of COVID-19 and could be used as an effective tool in setting of triage in high-prevalence areas.</p>","PeriodicalId":56282,"journal":{"name":"Journal of the Belgian Society of Radiology","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894373/pdf/","citationCount":"0","resultStr":"{\"title\":\"Performance of Low-Dose Chest CT as a Triage Tool for Suspected COVID-19 Patients.\",\"authors\":\"Jeroen Desmet, Charlotte Biebaû, Walter De Wever, Lesley Cockmartin, Verbraeken Viktor, Johan Coolen, Johny Verschakelen, Adriana Dubbeldam\",\"doi\":\"10.5334/jbsr.2319\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate the role of low-dose chest computed tomography (CT) imaging in the triage of patients suspected of coronavirus disease 2019 (COVID-19) in an emergency setting.</p><p><strong>Materials and methods: </strong>Data from 610 patients admitted to our emergency unit from March 20, 2020, until April 11, 2020, with suspicion of COVID-19 were collected. Diagnostic values of low-dose chest CT for COVID-19 were calculated using consecutive reverse-transcription polymerase chain reaction (RT-PCR) tests and bronchoalveolar lavage (BAL) as reference. Comparative analysis of the 199 COVID-19 positive versus 411 COVID-19 negative patients was done with identification of risk factors and predictors of worse outcome.</p><p><strong>Results: </strong>Sensitivity and specificity of low-dose CT for the diagnosis of COVID-19 respectively ranged from 75% (150/199) to 88% (175/199) and 94% (386/411) to 99% (386/389), depending on the inclusion of inconclusive results. On multivariate analysis, a higher body mass index (BMI), fever, and dyspnea on admission were risk factors for COVID-19 (all p-values < 0.05). The mortality rate was 12.6% (25/199). 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引用次数: 0
摘要
目的：研究低剂量胸部计算机断层扫描（CT）成像在急诊疑似冠状病毒病2019（COVID-19）患者分诊中的作用：收集2020年3月20日至2020年4月11日期间我院急诊科收治的610名疑似COVID-19患者的数据。以连续的反转录聚合酶链反应（RT-PCR）检测和支气管肺泡灌洗（BAL）为参考，计算低剂量胸部 CT 对 COVID-19 的诊断价值。对199例COVID-19阳性和411例COVID-19阴性患者进行了比较分析，并确定了风险因素和预示不良结局的因素：结果：低剂量CT诊断COVID-19的敏感性和特异性分别为75%（150/199）至88%（175/199）和94%（386/411）至99%（386/389），取决于是否纳入不确定结果。多变量分析显示，较高的体重指数（BMI）、发热和入院时呼吸困难是COVID-19的风险因素（所有P值均小于0.05）。死亡率为 12.6%（25/199）。高年龄、高水平的 C 反应蛋白 (CRP) 和 D 二聚体是预示较差预后的因素（所有 p 值均小于 0.05）：结论：低剂量胸部 CT 对怀疑 COVID-19 的无症状患者具有较高的特异性和中高灵敏度，可作为高发地区分诊的有效工具。
Performance of Low-Dose Chest CT as a Triage Tool for Suspected COVID-19 Patients.
Purpose: To investigate the role of low-dose chest computed tomography (CT) imaging in the triage of patients suspected of coronavirus disease 2019 (COVID-19) in an emergency setting.
Materials and methods: Data from 610 patients admitted to our emergency unit from March 20, 2020, until April 11, 2020, with suspicion of COVID-19 were collected. Diagnostic values of low-dose chest CT for COVID-19 were calculated using consecutive reverse-transcription polymerase chain reaction (RT-PCR) tests and bronchoalveolar lavage (BAL) as reference. Comparative analysis of the 199 COVID-19 positive versus 411 COVID-19 negative patients was done with identification of risk factors and predictors of worse outcome.
Results: Sensitivity and specificity of low-dose CT for the diagnosis of COVID-19 respectively ranged from 75% (150/199) to 88% (175/199) and 94% (386/411) to 99% (386/389), depending on the inclusion of inconclusive results. On multivariate analysis, a higher body mass index (BMI), fever, and dyspnea on admission were risk factors for COVID-19 (all p-values < 0.05). The mortality rate was 12.6% (25/199). Higher age and high levels of C-reactive protein (CRP) and D-dimers were predictors of worse outcome (all p-values < 0.05).
Conclusion: Low-dose chest CT has a high specificity and a moderate to high sensitivity in symptomatic patients with suspicion of COVID-19 and could be used as an effective tool in setting of triage in high-prevalence areas.
期刊介绍：
The purpose of the Journal of the Belgian Society of Radiology is the publication of articles dealing with diagnostic and interventional radiology, related imaging techniques, allied sciences, and continuing education.
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