COVID-19:诊断、治疗进展和疫苗开发。

IF 3.1 Q2 MICROBIOLOGY
Current Clinical Microbiology Reports Pub Date : 2021-01-01 Epub Date: 2021-02-15 DOI:10.1007/s40588-021-00157-9
Sabhiya Majid, Mosin S Khan, Samia Rashid, Ayesha Niyaz, Rabia Farooq, Showkat A Bhat, Hilal A Wani, Waseem Qureshi
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引用次数: 0

摘要

审查目的:人类目前正面临严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)的肆虐,这是一种高传播性和致病性的 RNA 病毒,导致了有史以来最严重的全球大流行病--2019 年冠状病毒病(COVID-19)。冠状病毒(CoVs)已成为一个重大的公共卫生问题。全球对 COVID-19 爆发的紧急应对措施是通过广泛的监测和遏制来限制 SARS-CoV-2 的传播。为控制 COVID-19 采用了各种治疗方案,使用已知的药物和药物组合来降低与 COVID-19 相关的发病率和死亡率。全球范围内开展了多方面的深入研究,包括研究这些病毒的分子和结构,揭示 COVID-19 的病理生理学和机理基础,以开发有效的预防、治疗药物和疫苗:最近的研究结果:尽管已经发现了新的药物靶点,但除了雷米地韦外,至今还没有针对 SARS-CoV-2 的经批准的抗病毒治疗方法。摘要:本综述强调了医护人员和科学界为成功应对 COVID-19 大流行所做的艰苦努力--尽管严重的疾病、生命和生计损失给人们留下了严重的印记。文章重点介绍了对各种治疗方案和抗病毒策略(包括中和抗体、潜在药物和药物靶点)的广泛研究,并阐明了各种诊断方案和令人惊叹的疫苗研发过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

COVID-19: Diagnostics, Therapeutic Advances, and Vaccine Development.

COVID-19: Diagnostics, Therapeutic Advances, and Vaccine Development.

Purpose of review: Human race is currently facing the wrath of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly transmittable and pathogenic RNA virus, causing coronavirus disease 2019 (COVID-19), the worst ever global pandemic. Coronaviruses (CoVs) have emerged as a major public health concern. Urgent global response to COVID-19 outbreak has been to limit spread of SARS-CoV-2 via extensive monitoring and containment. Various treatment regimens have been adopted to manage COVID-19, with known drugs and drug combinations used to decrease the morbidity and mortality associated with COVID-19. Intensive research on various fronts including studying molecular and structural aspects of these viruses and unraveling the pathophysiology and mechanistic basis of COVID-19 aimed at developing effective prophylactic, therapeutic agents and vaccines has been carried out globally.

Recent findings: No approved antiviral treatment except remdesivir exists for SARS-CoV-2 till date though novel drug targets have been identified. However, worldwide frantic and competitive vaccine development pharmaceutical race has borne fruit in the form of a number of promising candidate vaccines, out of which few have already received emergency use authorization by regulatory bodies in record time.

Summary: This review highlights the painstaking efforts of healthcare workers and scientific community to successfully address the COVID-19 pandemic-though damage in the form of severe illness, loss of lives, and livelihood has left a serious mark. Focusing on extensive research on various therapeutic options and antiviral strategies including neutralizing antibodies, potential drugs, and drug targets, light has been shed on various diagnostic options and the amazing vaccine development process as well.

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来源期刊
CiteScore
7.50
自引率
1.90%
发文量
9
期刊介绍: Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.
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