Chenxuan Wang, Jessica Murphy, Kerri Z Delaney, Natalie Khor, José A Morais, Michael A Tsoukas, Dana E Lowry, David M Mutch, Sylvia Santosa
{"title":"rs174537 FADS1多态性与腹部和股皮下脂肪组织免疫细胞谱之间的关系:一项针对肥胖成人的探索性研究","authors":"Chenxuan Wang, Jessica Murphy, Kerri Z Delaney, Natalie Khor, José A Morais, Michael A Tsoukas, Dana E Lowry, David M Mutch, Sylvia Santosa","doi":"10.1080/21623945.2021.1888470","DOIUrl":null,"url":null,"abstract":"<p><p>Fatty acid desaturase 1 (<i>FADS1</i>) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between <i>FADS1</i> variants and SAT inflammatory status. To advance this area, we conducted an exploratory study to investigate whether the common rs174537 polymorphism in <i>FADS1</i> was associated with immune cell profiles in abdominal and femoral SAT in individuals with obesity. <i>FADS1</i> gene expression and immune cell profiles in SAT depots were assessed by qPCR and flow cytometry, respectively. Although <i>FADS1</i> gene expression was associated with genotype, no associations were observed with immune cell profiles in either depot. Our study provides additional evidence that rs174537 in <i>FADS1</i> has minimal impact on inflammatory status in obese SAT.</p>","PeriodicalId":7226,"journal":{"name":"Adipocyte","volume":"10 1","pages":"124-130"},"PeriodicalIF":3.5000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21623945.2021.1888470","citationCount":"1","resultStr":"{\"title\":\"Association between rs174537 <i>FADS1</i> polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.\",\"authors\":\"Chenxuan Wang, Jessica Murphy, Kerri Z Delaney, Natalie Khor, José A Morais, Michael A Tsoukas, Dana E Lowry, David M Mutch, Sylvia Santosa\",\"doi\":\"10.1080/21623945.2021.1888470\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Fatty acid desaturase 1 (<i>FADS1</i>) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between <i>FADS1</i> variants and SAT inflammatory status. To advance this area, we conducted an exploratory study to investigate whether the common rs174537 polymorphism in <i>FADS1</i> was associated with immune cell profiles in abdominal and femoral SAT in individuals with obesity. <i>FADS1</i> gene expression and immune cell profiles in SAT depots were assessed by qPCR and flow cytometry, respectively. Although <i>FADS1</i> gene expression was associated with genotype, no associations were observed with immune cell profiles in either depot. Our study provides additional evidence that rs174537 in <i>FADS1</i> has minimal impact on inflammatory status in obese SAT.</p>\",\"PeriodicalId\":7226,\"journal\":{\"name\":\"Adipocyte\",\"volume\":\"10 1\",\"pages\":\"124-130\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/21623945.2021.1888470\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Adipocyte\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/21623945.2021.1888470\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Adipocyte","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/21623945.2021.1888470","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.
Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status. To advance this area, we conducted an exploratory study to investigate whether the common rs174537 polymorphism in FADS1 was associated with immune cell profiles in abdominal and femoral SAT in individuals with obesity. FADS1 gene expression and immune cell profiles in SAT depots were assessed by qPCR and flow cytometry, respectively. Although FADS1 gene expression was associated with genotype, no associations were observed with immune cell profiles in either depot. Our study provides additional evidence that rs174537 in FADS1 has minimal impact on inflammatory status in obese SAT.
期刊介绍：
Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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