三种锰(III)卟啉配合物与过氧化氢和亚硝酸盐催化酪氨酸硝化的氧化活性。

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metallomics Pub Date : 2021-03-17 DOI:10.1093/mtomcs/mfab005
Jiayu Li, Jingjing Wei, Zhonghong Gao, Guochuan Yin, Hailing Li
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引用次数: 1

摘要

了解mniii -卟啉(MnTPPS、MnTMPyP或mntbbap)的毒理学特性,为开发其作为蛋白酪氨酸硝化引起的炎症性疾病的治疗药物提供重要的生化依据。在这里,我们全面了解了这些mniii -卟啉的ph依赖性氧化还原行为及其在H2O2和NO2-存在下催化牛血清白蛋白(BSA)硝化的结构效应。结果表明,MnTPPS和mntpap在生理接近条件下(pH值为8)对牛血清白蛋白硝化的催化效果较好,而在pH值为6和10时效果较差。MnTMPyP在所有测试的pH值(pH值6、8和10)下都没有催化牛血清白蛋白硝化的能力。动力学和活性中间体电化学测定表明,在H2O2/NO2-存在下,中心金属阳离子的ph依赖性氧化还原行为和卟啉衍生物的抗氧化能力共同影响了3种mniii -卟啉在牛血清白蛋白硝化中的催化活性。这些综合研究mniii -卟啉对牛血清白蛋白硝化的氧化反应活性,可能为寻找基于锰的治疗炎症相关疾病的药物提供新的线索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The oxidative reactivity of three manganese(III) porphyrin complexes with hydrogen peroxide and nitrite toward catalytic nitration of protein tyrosine.

Understanding the toxicological properties of MnIII-porphyrins (MnTPPS, MnTMPyP, or MnTBAP) can provide important biochemical rationales in developing them as the therapeutic drugs against protein tyrosine nitration-induced inflammation diseases. Here, we present a comprehensive understanding of the pH-dependent redox behaviors of these MnIII-porphyrins and their structural effects on catalyzing bovine serum albumin (BSA) nitration in the presence of H2O2 and NO2-. It was found that both MnTPPS and MnTBAP stand out in catalyzing BSA nitration at physiologically close condition (pH 8), yet they are less effective at pH 6 and 10. MnTMPyP was shown to have no ability to catalyze BSA nitration under all tested pHs (pH 6, 8, and 10). The kinetics and active intermediate determination through electrochemistry method revealed that both the pH-dependent redox behavior of the central metal cation and the antioxidant capability of porphin derivative contribute to the catalytic activities of three MnIII-porphyrins in BSA nitration in the presence of H2O2/NO2-. These comprehensive studies on the oxidative reactivity of MnIII-porphyrins toward BSA nitration may provide new clues for searching the manganese-based therapeutic drugs against the inflammation-related diseases.

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来源期刊
Metallomics
Metallomics 生物-生化与分子生物学
CiteScore
7.00
自引率
5.90%
发文量
87
审稿时长
1 months
期刊介绍: Global approaches to metals in the biosciences
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