疏水相互作用控制DNA和纤维素的自组装。

IF 7.2 2区 生物学 Q1 BIOPHYSICS
Björn Lindman, Bruno Medronho, Luís Alves, Magnus Norgren, Lars Nordenskiöld
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引用次数: 38

摘要

脱氧核糖核酸、DNA和纤维素分子在水系统中自组装。这种聚集是这些生物大分子发挥重要功能的基础。DNA和纤维素都有显著的极性和非极性部分,在亲水性和疏水性相互作用之间有一个微妙的平衡。与净电荷有关的亲水性相互作用已被深入研究并得到很好的理解。另一方面,氢键和疏水相互作用的详细作用仍然存在争议。研究发现,疏水相互作用在驱动重要过程中的贡献,如DNA的双螺旋形成和纤维素的水溶性溶解,占主导地位,而氢键的净贡献很小。在回顾不同相互作用对DNA和纤维素的作用时,比较表面活性剂的自组装特征是有用的,表面活性剂是两亲分子中最简单的例子。关于纤维素和DNA两亲性的相关信息可以从与表面活性剂的结合以及通过添加剂修饰疏水相互作用中获得。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hydrophobic interactions control the self-assembly of DNA and cellulose.

Desoxyribosenucleic acid, DNA, and cellulose molecules self-assemble in aqueous systems. This aggregation is the basis of the important functions of these biological macromolecules. Both DNA and cellulose have significant polar and nonpolar parts and there is a delicate balance between hydrophilic and hydrophobic interactions. The hydrophilic interactions related to net charges have been thoroughly studied and are well understood. On the other hand, the detailed roles of hydrogen bonding and hydrophobic interactions have remained controversial. It is found that the contributions of hydrophobic interactions in driving important processes, like the double-helix formation of DNA and the aqueous dissolution of cellulose, are dominating whereas the net contribution from hydrogen bonding is small. In reviewing the roles of different interactions for DNA and cellulose it is useful to compare with the self-assembly features of surfactants, the simplest case of amphiphilic molecules. Pertinent information on the amphiphilic character of cellulose and DNA can be obtained from the association with surfactants, as well as on modifying the hydrophobic interactions by additives.

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来源期刊
Quarterly Reviews of Biophysics
Quarterly Reviews of Biophysics 生物-生物物理
CiteScore
12.90
自引率
1.60%
发文量
16
期刊介绍: Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.
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