LAPTM5在睾丸生殖细胞肿瘤的诊断和预后中起关键作用。

Xiunan Li, Yu Su, Jiayao Zhang, Ye Zhu, Yingkun Xu, Guangzhen Wu
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引用次数: 0

摘要

目的:睾丸生殖细胞瘤(TGCT)是一种早期诊断率低、病死率高的恶性肿瘤。方法:利用生物信息学分析作为一种准确、高效、经济的方法,寻找新的生物标志物来预测该肿瘤的诊断和预后。结果:我们的研究使用GEO和TCGA数据库检测到39个上调和589个下调的差异表达基因(deg)。为了确定DEGs的功能,使用KOBAS网站和String数据库进行GO功能分析、三途径分析(KEGG、REACTOME和PANTHER)和蛋白质-蛋白质相互作用网络。通过对GEPIA和TIMER的一系列分析,包括差异表达,我们发现了一个与TGCT预后和诊断相关的候选基因。LAPTM5还与CD8+ T细胞和PDCD1表达相关,提示其可能影响免疫浸润。结论:LAPTM5为枢纽基因,可作为TGCT诊断和预后的潜在生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

LAPTM5 Plays a Key Role in the Diagnosis and Prognosis of Testicular Germ Cell Tumors

LAPTM5 Plays a Key Role in the Diagnosis and Prognosis of Testicular Germ Cell Tumors

Objective. Testicular germ cell tumors (TGCT) are a serious malignant tumor with low early diagnosis rates and high mortality. Methods. To investigate novel biomarkers to predict the diagnosis and prognosis of this cancer, bioinformatics analysis was used as an accurate, efficient, and economical method. Results. Our study detected 39 upregulated and 589 downregulated differentially expressed genes (DEGs) using the GEO and TCGA databases. To identify the function of DEGs, GO functional analysis, three pathway analysis (KEGG, REACTOME, and PANTHER), and protein-protein interaction network were performed using the KOBAS website, as well as the String database. After a series of analyses in GEPIA and TIMER, including differential expression, we found one candidate gene related to the prognosis and diagnosis of TGCT. LAPTM5 was also associated with CD8+ T cell and PDCD1 expression, which suggests that it may affect immune infiltration. Conclusions. LAPTM5 was identified as a hub gene, which could be used as a potential biomarker for TGCT diagnosis and prognosis.

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来源期刊
Comparative and Functional Genomics
Comparative and Functional Genomics 生物-生化与分子生物学
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