高亲和多巴胺D2受体在大鼠兴奋毒性损伤的内嗅皮质,精神分裂症的动物模型的比例增加

Tomiki Sumiyoshi , Philip Seeman , Takashi Uehara , Hiroko Itoh , Masahiko Tsunoda , Masayoshi Kurachi
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引用次数: 19

摘要

左内嗅皮质(EC)的兴奋性毒性病变引起多巴胺超敏感。为了确定这些病变是否选择性地改变了多巴胺D2受体(D2 high)的高亲和力状态,我们通过损伤大鼠和假手术动物纹状体中多巴胺和[3H]多潘立酮的竞争来测量这些高亲和力状态。在ec损伤大鼠中,d2高位点的比例显著增加了200%,而多巴胺/[3H]SCH23390竞争测量的d1高位点的比例没有改变。这些结果为EC损伤大鼠行为超敏提供了生化基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increased proportion of high-affinity dopamine D2 receptors in rats with excitotoxic damage of the entorhinal cortex, an animal model of schizophrenia

Excitotoxic lesions of the left entorhinal cortex (EC) cause dopamine supersensitivity. In order to determine if these lesions selectively alter the high-affinity state of dopamine D2 receptors (D2High), these high-affinity states were measured by competition between dopamine and [3H]domperidone in striata from lesioned rats and sham-operated animals. The proportion of D2High sites was significantly elevated by 200% in the EC-lesioned rats while that of the D1High sites, measured by dopamine/[3H]SCH23390 competition, was unaltered. These results provide a biochemical basis for behavioral supersensitivity in rats with EC lesions.

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