{"title":"青光眼视网膜神经节细胞死亡:机制和神经保护策略。","authors":"Markus H Kuehn, John H Fingert, Young H Kwon","doi":"10.1016/j.ohc.2005.04.002","DOIUrl":null,"url":null,"abstract":"<p><p>Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.</p>","PeriodicalId":82231,"journal":{"name":"Ophthalmology clinics of North America","volume":"18 3","pages":"383-95, vi"},"PeriodicalIF":0.0000,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ohc.2005.04.002","citationCount":"210","resultStr":"{\"title\":\"Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.\",\"authors\":\"Markus H Kuehn, John H Fingert, Young H Kwon\",\"doi\":\"10.1016/j.ohc.2005.04.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.</p>\",\"PeriodicalId\":82231,\"journal\":{\"name\":\"Ophthalmology clinics of North America\",\"volume\":\"18 3\",\"pages\":\"383-95, vi\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ohc.2005.04.002\",\"citationCount\":\"210\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmology clinics of North America\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ohc.2005.04.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology clinics of North America","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.ohc.2005.04.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.
Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.
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