{"title":"福氏志贺氏菌Y血清型候选疫苗SFL124起源于血清型2a背景","authors":"Fleur Roberts, Amy V. Jennison, Naresh K. Verma","doi":"10.1016/j.femsim.2005.05.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Shigella flexneri</span></span> is endemic in most developing countries and responsible for the highest mortality rate among the <em>Shigella</em><span> species. The attenuated serotype Y </span><em>S. flexneri</em><span> strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of </span><em>gtrII</em><span> homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.</span></p></div>","PeriodicalId":12220,"journal":{"name":"FEMS immunology and medical microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.femsim.2005.05.002","citationCount":"8","resultStr":"{\"title\":\"The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background\",\"authors\":\"Fleur Roberts, Amy V. Jennison, Naresh K. Verma\",\"doi\":\"10.1016/j.femsim.2005.05.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Shigella flexneri</span></span> is endemic in most developing countries and responsible for the highest mortality rate among the <em>Shigella</em><span> species. The attenuated serotype Y </span><em>S. flexneri</em><span> strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of </span><em>gtrII</em><span> homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.</span></p></div>\",\"PeriodicalId\":12220,\"journal\":{\"name\":\"FEMS immunology and medical microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.femsim.2005.05.002\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FEMS immunology and medical microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0928824405001185\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEMS immunology and medical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0928824405001185","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
摘要
福氏志贺氏菌是大多数发展中国家的地方病，在志贺氏菌种类中造成的死亡率最高。福氏Y S. flexneri血清型减毒株SFL124已被用作亲本株，用于开发表达多种o抗原结构的重组疫苗。在研制这种多价疫苗的过程中，在SFL124中发现了一个与gtrII同源的区域。对该区域的测序和分析显示，在Y血清型疫苗株SFL124中存在插入元件中断血清型2a血清型转化位点。目前的数据表明SFL124来源于血清型2a背景。
The Shigella flexneri serotype Y vaccine candidate SFL124 originated from a serotype 2a background
Shigella flexneri is endemic in most developing countries and responsible for the highest mortality rate among the Shigella species. The attenuated serotype Y S. flexneri strain SFL124 has been used as the parental strain for the development of recombinant vaccines expressing multiple O-antigen structures. During the development of one such multivalent vaccine, a region of gtrII homology was found in SFL124. Sequencing and analysis of this region revealed the presence of an insertion element interrupted serotype 2a serotype-conversion locus in the serotype Y vaccine strain SFL124. The data presented suggests that SFL124 has derived from a serotype 2a background.
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