神经节阻滞不能预防人类皮质醇诱导的高血压。

IF 2.4 4区医学 Q3 PHARMACOLOGY & PHARMACY

Clinical and Experimental Pharmacology and Physiology Pub Date : 2005-04-01 DOI:10.1111/j.1440-1681.2005.04220.x

Paula M Williamson, Sim Hom Tam, John J Kelly, Judith A Whitworth

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引用次数: 5

摘要

1. 本研究的目的是评估神经节阻断对皮质醇治疗的人类受试者血压的影响。2. 四名健康男性受试者接受皮质醇80毫克/天的治疗，为期5天。静脉注射三甲撒芬阻断神经节。3.在预处理阶段或皮质醇治疗的最后一天，神经节阻断没有显著改变血压。4. 结合我们之前的观察，交感神经活动不会因皮质醇而改变或减少，这些结果表明，皮质醇诱导的人类高血压并不是自主神经系统过度活跃的结果。

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Ganglion blockade does not prevent cortisol-induced hypertension in man.

1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system.

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来源期刊

Clinical and Experimental Pharmacology and Physiology PHARMACOLOGY & PHARMACY-PHYSIOLOGY

自引率

0.00%

发文量

128

期刊介绍： Clinical and Experimental Pharmacology and Physiology is an international journal founded in 1974 by Mike Rand, Austin Doyle, John Coghlan and Paul Korner. Our focus is new frontiers in physiology and pharmacology, emphasizing the translation of basic research to clinical practice. We publish original articles, invited reviews and our exciting, cutting-edge Frontiers-in-Research series’.