[Clinical analysis of intrahepatic cholestasis during pregnancy in 150 patients].

Objective: To explore the effect of intrahepatic cholestasis of pregnancy (ICP) on the mother and fetus, and to assess the clinical value of nonstress test.

Methods: The symptoms, biochemical examinations, fetal monitoring, and pregnant outcomes of 150 patients with ICP were analyzed retrospectively in our hospital.

Results: There was no linear relation among serum cholanic acid, glutamic-pyruvic transaminase, total bilirubin, and gestational age when skin pruritus of pregnant women appeared, but there was positive correlation among the neonate status, meconium-stained amniotic fluid, and the onset time of pruritus. There was no correlation between the amount of postpartum hemorrhage and the newborn Apgar scores. No significant difference was found in perinatal prognosis The appearance of skin between normal and abnormal outcomes in the nonstress test.

Conclusion: pruritus can be a sign of the state of ICP patients. To carefully monitor and comprehensively and continuously estimate the fetal state, and to terminate the pregnancy at proper time are very important to improve the prognosis of perinatal infants.