人类先天性 B 细胞:宿主防御与自身免疫之间的联系?

Springer seminars in immunopathology Pub Date : 2005-03-01 Epub Date: 2005-01-05 DOI:10.1007/s00281-004-0188-9
Eric C B Milner, Jennifer Anolik, Amedeo Cappione, Iñaki Sanz
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引用次数: 0

摘要

B 细胞通过其抗原呈递能力以及细胞因子和趋化因子的产生发挥着多种免疫调节作用。B 细胞的先天性免疫激活可通过产生天然交叉反应抗体、维持 B 细胞记忆和发挥免疫调节功能来发挥有益的作用,从而提供对自身免疫的保护。在这篇文章中,我们回顾了人类 B 细胞群及其功能特性,并特别关注天生具有自反应性的 B 细胞群,它们似乎在先天性免疫中发挥着重要的生理作用,但如果被选入适应性免疫反应,则似乎会成为系统性红斑狼疮的致病因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human innate B cells: a link between host defense and autoimmunity?

B cells play a variety of immunoregulatory roles through their antigen-presentation ability and through cytokine and chemokine production. Innate immune activation of B cells may play a beneficial role through the generation of natural cross-reactive antibodies, by maintaining B cell memory and by exercising immunomodulatory functions that may provide protection against autoimmunity. In this article, we review human B cell populations and their functional properties, with a particular focus on a population of inherently autoreactive B cells, which seem to play an important physiological role in innate immunity, but which, if selected into adaptive immune responses, appear to become pathogenic agents in systemic lupus erythematosus.

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