同型半胱氨酸与健康老年人认知能力的关系。

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2004-01-01 DOI:10.1016/j.archger.2004.04.045

G. RAVAGLIA , P. FORTI , F. MAIOLI , R.C. SCALI , L. SACCHEITTI , T. TALERICO , V. MANTOVANI , M. BIANCHIN

引用次数: 0

摘要

高同型半胱氨酸血症是痴呆的一个危险因素，但关于其与正常衰老过程中特定认知能力的关系的数据很少。我们从大脑衰老咨询研究中招募了62名年龄在65-91岁之间的健康和认知正常的受试者。采用以下神经心理测试:(i)由7个部分组成的智力退化测试(MDB): Rey’s 15个单词的即时和延迟回忆、单词流畅性、句子结构、Raven’s渐进矩阵’47、即时视觉记忆、手绘绘画和带地标的绘画。(ii)散文记忆测试。(iii) Corsi模块敲击任务。(iv)迷你精神状态检查(MMSE)分数。我们测量了血浆总同型半胱氨酸(tHcy)、血清叶酸、维生素B12和血浆维生素B6。多变量调整线性回归分析显示血浆tHcy与MMSE评分(b= -0.01 2,p < 0.001)和单词流畅性(b= -0.009, p = 0.021)呈显著负相关。在句子结构方面也发现了非显著的负相关趋势(b = -0.006, p = 0.076)。我们可以得出这样的结论:在健康的老年受试者中，血浆中tHcy的增加与血管性痴呆和阿尔茨海默氏痴呆患者在语言能力的特定测量中表现较差有关。该研究表明，血浆tHcy可能是认知障碍的早期标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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HOMOCYSTEINE AND COGNITIVE PERFORMANCE IN HEALTHY ELDERLY SUBJECTS

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.