大肠杆菌和植物中过敏原的表达——利弊。

Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M Pub Date : 2003-01-01

Heimo Breiteneder, Birgit Wagner

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引用次数: 0

摘要

重组过敏原正迅速成为I型过敏性疾病诊断和治疗的首选试剂。因此，目前可用的生产重组蛋白的不同方法引起了过敏症专家的极大兴趣。毫无疑问，细菌表达将继续发挥关键作用。此外，基于植物的表达系统将需要克服大肠杆菌系统固有的问题，并允许产生糖过敏原或更复杂折叠的过敏原。

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Expression of allergens in E. coli and plants--benefits and drawbacks.

Recombinant allergens are quickly becoming the reagents of choice for diagnosis and therapy of type I allergic diseases. Consequently, the different methods for the production of recombinant proteins that are available today are of great interest to allergologists. Without doubt, bacterial expression will continue to play a pivotal role. In addition, plant-based expression systems will be needed to overcome problems inherent in the E. coli systems and to allow the production of glycoallergens or allergens of more complex folding.

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Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M

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