Carla Lobina , Giancarlo Colombo , Gian Luigi Gessa , Mauro A.M. Carai
{"title":"完成第10代ghb敏感大鼠和ghb抗性大鼠的双向选择性育种","authors":"Carla Lobina , Giancarlo Colombo , Gian Luigi Gessa , Mauro A.M. Carai","doi":"10.1016/j.brainresprot.2004.02.001","DOIUrl":null,"url":null,"abstract":"<div><p>The present paper describes the completion of the bidirectional selective breeding of γ-hydroxybutyric acid (GHB)-sensitive (GHB-S) and GHB-resistant (GHB-R) rats, which display opposite sensitivity to the sedative/hypnotic effect of 1 g/kg GHB. Completion of the selective breeding process was achieved by the F10, when 100% of rats of each line fulfilled the selection criterion. GHB-S and GHB-R rats may constitute a valuable tool for investigations on GHB physiology and pharmacology.</p></div>","PeriodicalId":79477,"journal":{"name":"Brain research. Brain research protocols","volume":"13 1","pages":"Pages 53-56"},"PeriodicalIF":0.0000,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresprot.2004.02.001","citationCount":"7","resultStr":"{\"title\":\"Completion by the 10th generation of the bidirectional selective breeding of GHB-sensitive and GHB-resistant rats\",\"authors\":\"Carla Lobina , Giancarlo Colombo , Gian Luigi Gessa , Mauro A.M. Carai\",\"doi\":\"10.1016/j.brainresprot.2004.02.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The present paper describes the completion of the bidirectional selective breeding of γ-hydroxybutyric acid (GHB)-sensitive (GHB-S) and GHB-resistant (GHB-R) rats, which display opposite sensitivity to the sedative/hypnotic effect of 1 g/kg GHB. Completion of the selective breeding process was achieved by the F10, when 100% of rats of each line fulfilled the selection criterion. GHB-S and GHB-R rats may constitute a valuable tool for investigations on GHB physiology and pharmacology.</p></div>\",\"PeriodicalId\":79477,\"journal\":{\"name\":\"Brain research. Brain research protocols\",\"volume\":\"13 1\",\"pages\":\"Pages 53-56\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.brainresprot.2004.02.001\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain research. Brain research protocols\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1385299X04000182\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain research. Brain research protocols","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1385299X04000182","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Completion by the 10th generation of the bidirectional selective breeding of GHB-sensitive and GHB-resistant rats
The present paper describes the completion of the bidirectional selective breeding of γ-hydroxybutyric acid (GHB)-sensitive (GHB-S) and GHB-resistant (GHB-R) rats, which display opposite sensitivity to the sedative/hypnotic effect of 1 g/kg GHB. Completion of the selective breeding process was achieved by the F10, when 100% of rats of each line fulfilled the selection criterion. GHB-S and GHB-R rats may constitute a valuable tool for investigations on GHB physiology and pharmacology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
