骨化三醇对免疫系统的影响:治疗肾小球肾炎的新可能性。

IF 2.4 4区医学 Q3 PHARMACOLOGY & PHARMACY

Clinical and Experimental Pharmacology and Physiology Pub Date : 2003-11-01 DOI:10.1046/j.1440-1681.2003.03919.x

Vincenzo Panichi, Massimiliano Migliori, Daniele Taccola, Cristina Consani, Luca Giovannini

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引用次数: 9

摘要

1. 1,25-二羟基维生素D3 (1,25(OH)2D3)是维生素D的激素形式，被广泛认为在钙和磷酸盐的体内平衡中起着核心作用。然而，越来越清楚的是，甾醇在调节细胞生长、造血组织和免疫系统以及调节几种内分泌腺的激素分泌方面也起着重要作用。2. 本文综述了1,25(OH)2D3调节免疫功能的一些机制。此外，一些关于骨化三醇在几种肾脏疾病实验动物模型中的作用的研究报道，为肾小球肾炎的治疗提供了新的可能性。

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Effects of calcitriol on the immune system: new possibilities in the treatment of glomerulonephritis.

1. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonal form of vitamin D, is widely appreciated to play a central role in calcium and phosphate homeostasis. However, it is becoming increasingly clear that the sterol also play an important role in the regulation of cellular growth, haematopoietic tissues and the immune system, as well as in the modulation of hormone secretion by several endocrine glands. 2. In the present review, some of the mechanisms by which 1,25(OH)2D3 regulates immune function are highlighted. Moreover, a number of studies on the effects of calcitriol in several experimental animal models of renal disease are reported, suggesting new possibilities in the therapy of glomerulonephritis.

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来源期刊

Clinical and Experimental Pharmacology and Physiology PHARMACOLOGY & PHARMACY-PHYSIOLOGY

自引率

0.00%

发文量

128

期刊介绍： Clinical and Experimental Pharmacology and Physiology is an international journal founded in 1974 by Mike Rand, Austin Doyle, John Coghlan and Paul Korner. Our focus is new frontiers in physiology and pharmacology, emphasizing the translation of basic research to clinical practice. We publish original articles, invited reviews and our exciting, cutting-edge Frontiers-in-Research series’.